Apresentação Pessoal

Sónia Fraga, PhD

Assistant Researcher, Associated Laboratory REQUIMTE

EDUCATION
PhD in Human Biology, Faculty of Medicine, University of Porto (2006)
Degree in Biology, Faculty of Sciences, University of Porto (1998)

RESEARCH INTERESTS

Biomedical applications and potential health risks of nanomaterials. In vitro and in vivo assessment of metal nanoparticles interactions and effects on biological systems: uptake kinetics and internalization pathways, biodistribution, cellular responses and mechanisms of toxicity.

POST-GRADUATE SCIENTIFIC TRAINING
Visiting Scientist
National Center for Toxicological Research, Food and Drug Administration (USA, 2010)
Georgetown University School of Medicine (USA, 2002)

SELECTED PUBLICATIONS IN INTERNATIONAL JOURNALS 

Morais T, Soares ME, Duarte JA, Soares L, Maia S, Gomes P, Pereira E, Fraga S, Carmo H, Bastos ML (2012). Effect of surface coating on the biodistribution profile of gold nanoparticles in the rat. Eur J Pharm Biopharm. 80(1):185-193.

Quintas C, Fraga S, Gonçalves J, Queiroz G (2011). P2Y receptors on astrocytes and microglia mediate opposite effects in astroglial proliferation. Purinergic Signal. 7(2): 251-263.

Quintas C, Fraga S, Gonçalves J, Queiroz G (2011). Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate and 2-methylthioadenosine-5'-diphosphate: mechanisms involved. Neuroscience 182: 32-42.

Simão S, Fraga S, Jose PA, Soares-da-Silva P (2008). Oxidative stress and α₁-adrenoceptor-mediated stimulation of Cl^-/HCO₃^- exchanger in immortalized SHR proximal tubular epithelial cells. Br J Pharmacol. 153 (7): 1445-1455.

Magro F, Fraga S, Soares-da-Silva P (2007). Short-term regulation of intestinal epithelial Na⁺/H⁺ exchanger by Gi_α1,2-coupled 5-HT_1A and G_q/11-coupled 5-HT₂ receptors. Life Sciences 81 (7): 560-569.

Fraga S, Jose PA, Zandi-Nejad K, Mount DB, Soares-da-Silva P (2006). Dopamine D₁ receptor-mediated inhibition of Cl^-/HCO₃^- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK6). Cell Physiol Biochem 18 (6): 347-360.

Fraga S, Pinho MJ, Soares-da-Silva P (2005). Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cell lines. Amino Acids 29 (3): 229-233.

Magro F, Fraga S, Soares-da-Silva P (2005). Signaling of short- and long-term regulation of intestinal epithelial type 1 Na⁺/H⁺ exchanger by interferon-g. Br J Pharmacol. 145(1): 93-103.

Fraga S, Jose PA, Soares-da-Silva P (2004). Involvement of G protein coupled-receptor kinase 4 and 6 in rapid desensitization of dopamine D₁ receptor in rat IEC-6 intestinal epithelial cells. Am J Physiol Regul Integr Comp Physiol. 287(4): R772-9.

Magro F, Fraga S, Ribeiro T & Soares-da-Silva P (2004). Intestinal Na⁺-K⁺-ATPase activity and molecular events downstream of interferon-gamma receptor stimulation. Br J Pharmacol. 142 (8): 1281-1292.

Fraga S, Serrão MP, Soares-da-Silva P (2002). L-type amino acid transporters in two intestinal epithelial cells lines function as exchangers with neutral amino acids. J Nutr. 132:733-738.

Fraga S, Serrão MP, Soares-da-Silva P (2002). The L-3,4-dihydroxyphenylalanine transporter in human and rat epithelial intestinal cells is a type 2 hetero amino acid exchanger. Eur J Pharmacol. 441(3): 127-35.

Magro F, Vieira-Coelho MA, Fraga S, Serrão MP, Tavarela -Veloso F, Soares-da-Silva P (2002). Impaired synthesis or cellular storage of norepinephrine, dopamine and 5-hydroxytryptamine in human inflammatory bowel disease. Dig Dis Sci. 47(1): 216-224.

Áreas de Interesse

1. Health sciences > Pharmacological sciences > Toicology
2. Natural sciences > Biological sciences > Biology
3. Technological sciences > Technology > Biotecnology > Nanobiotechnology