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MSc in Analytical, Clinical and Forensic Toxicology

General information

Official Code: 6257
Acronym: TACF
Description: O presente CE tem como principal objetivo formar Mestres na área da Toxicologia, com conhecimento aprofundado nas suas vertentes analítica, clínica e forense. O curso, de 120 ECTS, tem no 1º ano uma organização curricular que pretende desenvolver competências em aspetos teóricos, relacionados com conhecimentos base desta área científica, tais como mecanismos de toxicidade dos tóxicos, conhecimentos fármaco- e toxicocinéticos, aspetos laboratoriais, tais como análises toxicológicas de vários grupos de compostos com interesse clínico e forense (solventes, drogas de abuso, fármacos, metais), aspetos clínicos, como a sintomatologia das intoxicações e sua caracterização, e aspetos forenses, tais como questões jurídico-legais relacionadas com a taxa de alcoolémia e o abuso de drogas. No 1º ano, o estudante realiza um trabalho de seminário, com uma vertente de preparação para a dissertação/projeto que decorre no 2º ano curricular. O objetivo final é formar especialistas com competências para desempenho profissional em centros de investigação, laboratórios de análises químico-biológicas, em hospitais e farmácias (em particular, as hospitalares), centros de anti-venenos, nas delegações do Instituto de Medicina Legal, empresas (por exemplo ao nível de segurança no trabalho ou regulamentação) ou como peritos jurídico-legais.

Certificates

  • MSc in Analytical, Clinical and Forensic Toxicology (120 ECTS credits)
  • Master's Course in Analytical, Clinical and Forensic Toxicology (60 ECTS credits)

Courses Units

Toxicological Analysis I

TA07004 - ECTS

The UC Toxicological Analysis I has the main objective of developing the competence of the students in two important domains:

1. Understanding toxicodynamics and practical use of biomarkers of exposure and effect, for the early detection of adverse effects of the compounds.

The screening of toxic effects through the non-invasive evaluation of biomarkers (ex: micronucleus as indicator of effect/genotoxicity).

The evaluation of biomarkers of effect resulting from the exposure to biomaterials used as medical devices in a safety perspective.

Understanding the models used for the assessment of toxicity/safety of exposure to xenobiotics alone and in mixtures.

2. On a clinical and forensic perspective, analysing and understanding the general aspects of fundamental and analytical toxicology of exposure to substances of the groups of: (i) volatiles; (ii) metals; (iii) toxic plants.

 

 

Toxicological Analysis II

TA07005 - ECTS

The Toxicological Analysis II UC has the main objective of developing the competence of the students of the MSc in Analytical, Clinical and Forensic Toxicology in analyzing and understanding the general aspects of analytical toxicology in the ambit of the non-volatile organic substances (with focus on drugs, drugs of abuse and pesticides, among others). It is also intended that the students develop the capacity to use the gained knowledge in an integrated fashion for the overall evaluation of the toxicity of xenobiotics, in particular in what concerns the contribution of analytical toxicology for toxicological risk assessment.

Juridical and Forensic Aspects

TA07012 - ECTS Regarding Legal Sciences, it is intended that students familiarize themselves with matters relating to general principles of law applicable to the forensic context.

Certification and Quality Control

TA07006 - ECTS

Understand the principles and foundations of certification (of quality management systems), quality control and accreditation in the laboratory context, with a focus on clinical and forensic laboratories.

Develop technical and methodological skills to implement and manage quality management systems (QMS).

Enable students to implement internal quality control (IQC) and external quality assessment (EQA) programs.

Enable students to act in promoting continuous improvement in laboratory activities based on international standards and good practices.

Enable students to act in auditing and conformity assessment processes.

Pharmacokinetic, Toxicokinetic, Pharmacogenetic and Necrokinetic

TA07013 - ECTS

The course aims to develop students' competence in the analysis and understanding of associated bioavailability and consequent biological activity of xenobiotics mechanisms, be they drugs, toxic or environmental and food contaminants. It also intends that students gain the ability to use the knowledge acquired in the field of Forensic Medicine and Toxicology, particularly in understanding the mechanisms of toxicity of xenobiotics, the symptoms of poisoning and judicial-legal issues, such as those related to the rate blood alcohol and drug abuse. 
More particularly, this course has the following Learning Outcomes: 

  • Capacity to interpret and predict the changes in pharmacological doses as a result of pharmacokinetic variability of drugs and pathophysiological conditions
  • Recognize the factors that modulate the biological activity of xenobiotics in the body 
  • Develop the ability to critical analysis of the results of analytical toxicology


Within the scope of transversal competences, this Course Unit aims to contribute to the development of the following competences as learning outcomes:

  • Cognitive Competencies: analytical, critical, reflective and creative thinking;
  • Methodological skills: time management, problem-solving ability, decision-making
  • Social Competences: interpersonal communication, collaborative work

Analytical Methods in Toxicology

TA07008 - ECTS Globally (i.e., with the theoretical and laboratory classes) it is intended to develop in the students the ability to apply the instrumental methods of analysis in real situations and the acquisition of skills as laboratory analysts. Specifically it is intended that students become able to:
i) Recognize the importance of instrumental methods of analysis; ii) know the main instrumental techniques and the basics of instrumentation; iii) Perform the development and validation of analytical procedures; iv) Perform the proper treatment of laboratory results.

Clinical Chemistry

TA07009 - ECTS The students should acquire the knowledge that allows the interpretation of laboratory analytical results, to identify and/or monitor changes of the action of toxic agents on key target organs of toxicity.

Seminary

TA07010 - ECTS

The UC Seminar aims at the student:

  • obtain knowledge and develop skills in the scientific field in which it intends to develop its master's dissertation to be held in the 2nd year of the Cycle of Studies
  • develop skills in bibliographic research
  • develop skills in writing a scientific paper
  • establish working link with the seminar and potentially the dissertation tutor.
Within the scope of transversal competences, this Course Unit aims to contribute to the development of the following competences as learning outcomes:
  • Cognitive Competencies: analytical, critical, reflective and creative thinking;
  • Methodological Competences: time management, planning capacity and digital competencies;
  • Social Competences: interpersonal communication, collaborative work.

Clinical Toxicology

TA07001 - ECTS

Present to Students the various domains of Clinical Toxicology:

  • in the Anti-Poison Information Center, as the first point of contact to be established in the event of suspected poisoning, and its operation
  • in the Hospital Emergency: measures of distress, life support and attempt to identify the causative agent of intoxication
  • in the individualization of therapy, applied to drugs with a narrow safety margin
  • in Occupational and Environmental Medicine, in monitoring the workers welfare and health, and in compliance with regulations
  • in the characterization of the main target organs of the toxic compounds and their early expression
  • in the interconnection with Analytical Toxicology (monitoring of exposure, effect and susceptibility biomarkers)
  • padagogical and scientific interchange for the knowledge of the Clinical Toxicology in Brazil.
Within the transversal skills, this course aims to contribute to the development of the following skills as learning outcomes:
  • Cognitive Competencies: analytical, critical, reflective and creative thinking;
  • Methodological Competences: time management and planning capacity;
  • Social Competences: interpersonal communication and collaborative work.

Forensic Toxicology

TA07002 - ECTS

To give an update vision of Forensic Toxicology, adressing on post-mortem analysis to identify the cause of death, to support the behavioral alteration by psychoactive compounds, to monitor drugs of abuse in a forensic perspective, and to carry out epidemiological studies to evaluate the dynamic of the compounds illegally used and/or regulated.

Within the transversal skills, this course aims to contribute to the development of the following skills as learning outcomes:

  • Cognitive Competencies: analytical, critical, reflective and creative thinking;
  • Methodological Competences: time management and planning capacity;
  • Social Competences: interpersonal communication and collaborative work.

 

Fundamental Toxicology

TA24016 - ECTS The students should be able to explain the main mechanisms and toxicological responses and apply this knowledge in the risk assessment of xenobiotics, whether they are drugs, toxins, or environmental and food contaminants.

Dissertation

TA22014 - ECTS The Dissertation course unit aims to enable the student to carry out independent scientific research, under tutorial supervision, and to produce a master’s thesis in the scientific area of Analytical, Clinical and Forensic Toxicology.

Project

TA22015 - ECTS In this programme, this modality may replace the dissertation, with the same objectives, competences, learning methodologies, and assessment methods applying.
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