Official Code: | 6257 |
Acronym: | TACF |
Description: | O presente CE tem como principal objetivo formar Mestres na área da Toxicologia, com conhecimento aprofundado nas suas vertentes analítica, clínica e forense. O curso, de 120 ECTS, tem no 1º ano uma organização curricular que pretende desenvolver competências em aspetos teóricos, relacionados com conhecimentos base desta área científica, tais como mecanismos de toxicidade dos tóxicos, conhecimentos fármaco- e toxicocinéticos, aspetos laboratoriais, tais como análises toxicológicas de vários grupos de compostos com interesse clínico e forense (solventes, drogas de abuso, fármacos, metais), aspetos clínicos, como a sintomatologia das intoxicações e sua caracterização, e aspetos forenses, tais como questões jurídico-legais relacionadas com a taxa de alcoolémia e o abuso de drogas. No 1º ano, o estudante realiza um trabalho de seminário, com uma vertente de preparação para a dissertação/projeto que decorre no 2º ano curricular. O objetivo final é formar especialistas com competências para desempenho profissional em centros de investigação, laboratórios de análises químico-biológicas, em hospitais e farmácias (em particular, as hospitalares), centros de anti-venenos, nas delegações do Instituto de Medicina Legal, empresas (por exemplo ao nível de segurança no trabalho ou regulamentação) ou como peritos jurídico-legais. |
The UC Toxicological Analysis I has the main objective of developing the competence of the students in two important domains:
1. Understanding toxicodynamics and practical use of biomarkers of exposure and effect, for the early detection of adverse effects of the compounds.
The screening of toxic effects through the non-invasive evaluation of biomarkers (ex: micronucleus as indicator of effect/genotoxicity).
The evaluation of biomarkers of effect resulting from the exposure to biomaterials used as medical devices in a safety perspective.
Understanding the models used for the assessment of toxicity/safety of exposure to xenobiotics alone and in mixtures.
2. On a clinical and forensic perspective, analysing and understanding the general aspects of fundamental and analytical toxicology of exposure to substances of the groups of: (i) volatiles; (ii) metals; (iii) toxic plants.
The Toxicological Analysis II UC has the main objective of developing the competence of the students of the MSc in Analytical, Clinical and Forensic Toxicology in analyzing and understanding the general aspects of analytical toxicology in the ambit of the non-volatile organic substances (with focus on drugs, drugs of abuse and pesticides, among others). It is also intended that the students develop the capacity to use the gained knowledge in an integrated fashion for the overall evaluation of the toxicity of xenobiotics, in particular in what concerns the contribution of analytical toxicology for toxicological risk assessment.
Understand the principles and foundations of certification (of quality management systems), quality control and accreditation in the laboratory context, with a focus on clinical and forensic laboratories.
Develop technical and methodological skills to implement and manage quality management systems (QMS).
Enable students to implement internal quality control (IQC) and external quality assessment (EQA) programs.
Enable students to act in promoting continuous improvement in laboratory activities based on international standards and good practices.
Enable students to act in auditing and conformity assessment processes.
The course aims to develop students' competence in the analysis and understanding of associated bioavailability and consequent biological activity of xenobiotics mechanisms, be they drugs, toxic or environmental and food contaminants. It also intends that students gain the ability to use the knowledge acquired in the field of Forensic Medicine and Toxicology, particularly in understanding the mechanisms of toxicity of xenobiotics, the symptoms of poisoning and judicial-legal issues, such as those related to the rate blood alcohol and drug abuse.
More particularly, this course has the following Learning Outcomes:
Within the scope of transversal competences, this Course Unit aims to contribute to the development of the following competences as learning outcomes:
The UC Seminar aims at the student:
Present to Students the various domains of Clinical Toxicology:
To give an update vision of Forensic Toxicology, adressing on post-mortem analysis to identify the cause of death, to support the behavioral alteration by psychoactive compounds, to monitor drugs of abuse in a forensic perspective, and to carry out epidemiological studies to evaluate the dynamic of the compounds illegally used and/or regulated.
Within the transversal skills, this course aims to contribute to the development of the following skills as learning outcomes: