QF13003 - ECTS

 It is intended that students know the techniques used in the official control of pharmaceutical products (raw materials and final products). To study and implement in an integrated way, the main methodologies used in the purification and pharmaceutical analysis as a basis for quality assessment and characterization of official substances and pharmaceuticals. The knowledge of the purity required for products of use in pharmacy and medicine, structure and organization of the main official codes, and of the importance of the reference substances and certificated materials allow the students to rationalize more efficiently the pharmaceutical analysis and fit it within the proper context. Objectives are also the use of appropriately techniques of separation, identification and determination as well as learning how to validate an analytical method.

QF13002 - ECTS

It is intended that students acquire a set of knowledge essential to follow the evolution that has been the application of the Natural Products in Medicinal Chemistry, especially in the search of new drugs, including the use as models for development, semi-synthesis and total synthesis of bioactive compounds, as well as important tools for investigating novel mechanisms of action or discovery of new receptors. Another objective is to present technologies based on the genetic manipulation of biosynthetic enzymes of natural products, particularly in combinatorial biosynthesis, as well as other strategies used to obtain biodiversity.

QF13001 - ECTS

In this UC it is intended that students acquire the general principles in pharmaceutical and medicinal chemistry and contact the sources, methodologies and strategies used to obtain new drugs and thus be able to propose molecular changes, interpret the structure-activity relationship (SAR) , metabolism and mechanisms of action at the molecular level for different groups of drugs.

With this objective it is intended that students:

* use appropriate terminology to explain basic chemical, pharmacological and therapeutic concepts;

* acquire, understand, apply and analyze information on the chemical structure of drugs and the relationship with therapeutic applications, as a tool for the discovery of new drugs;

* select a suitable drug candidate based on knowledge of the chemical, physical properties of a molecule;

* apply the knowledge of structural characteristics to predict mechanisms, adverse effects, metabolism, solubility, acid / base characteristics, potential drug interactions and therapeutic effects of potential drugs.

* have a perception of computational methods

* understand the management of intellectual property

They must acquire an overview of the drug development process from an industrial point of view and on clinical trials and safety.
More particularly, at the level of the therapeutic classes covered, students will be able to:

* acquire an overview of the pharmaceutical and medicinal chemistry of chemotherapic drugs.

* identify the chemical and / or pharmacological classification to which a drug belongs based on the pharmacophore;

* predict therapeutic applications for individual drugs based on knowledge of the chemical and / or pharmacological classification and based on the structure-activity relationship (SAR) and the structural characteristics responsible for the interaction with biological targets;

* select within a chemical and / or pharmacological class a lead compound based on structural characteristics that affect absorption, distribution, metabolism and excretion;

At the level of case studies of bioactive compounds in research, students should be able, in the context of research, to know how to apply the acquired knowledge and their ability to understand, as well as to solve problems, in new and unfamiliar situations, broad and multidisciplinary contexts.

With classes on application of concepts, students will have the opportunity to integrate knowledge, deal with complex or multidisciplinary issues, develop solutions and be able to communicate their conclusions and the knowledge and reasoning underlying them, whether to specialists or non-specialists, in a clear and unambiguous way.

In the laboratory component it is intended that they acquire skills in common techniques used in pharmaceutical and medicinal chemistry laboratories and related to the topics covered in theoretical classes.

QF13007 - ECTS

 

This UC aims at applying knowledge of chemistry, physics and molecular biology in the identification of those components and processes for the construction of nanomaterials, nanostructures and nanosystems with important application in therapy.

 

QF13004 - ECTS

 

The objective of this unit is to lead the students to understand the strategies and the methods applied to the synthesis of drugs and how this field is important in obtaining new drugs, such as novel or by molecular modification of a hit/lead compound. It is also intended that the students acquire a green chemistry point-of-view concerning the drug discovery and development process.

 

QF13009 - ECTS

Pharmacokinetic and toxicological studies must now be considered early in the design and development of new drugs. Consequently, Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) is today an essential subject on Medicinal Chemistry. The aim of this unit is to deepen knowledge of pharmacokinetic and toxicity from a medicinal chemistry perspective associated with the drug discovery and development. The overall objective of this unit is to provide students contact with the various strategies / methodologies for applying concepts of ADMET in planning and obtaining safer drugs.

In the end, the student should:

- acquire, understand, apply and analyze information on the pharmacokinetics and toxicity of drugs;

- acquire a set of knowledge essential to follow-up the process of multidimensional optimization in drug discovery and development;

- use appropriate terminology to explain Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) concepts;

- acquire ability to evaluate and implement drug-like profiles in a chemical entity;

- propose strategies for modifying the structure to improve solubility, increase permeability, reduce the efflux through the P-glycoprotein, improve the penetration of the blood-brain barrier, improve the stability in plasma and in solution, decrease the binding to plasma proteins, change/increase metabolic stability, improve the safety of drugs, among others.

At the level of case studies focusing on molecular modification strategies and methods for evaluating various aspects related to ADMET, students should be able, in the context of research, to know how to apply the acquired knowledge and their ability to understand, as well as to solve problems, in new and unfamiliar situations, broad and multidisciplinary contexts.

In the laboratory component it is intended that they acquire skills in common techniques used in pharmaceutical and medicinal chemistry laboratories and related to the topics covered in theoretical classes.

QF13010 - ECTS

It is intended that students acquire a set of knowledge on drug regulation
that allow:
to understand why medicines must be authorized and the design of the marketing authorization system,
the evaluation of the impact on the development and manufacturing process of new bioactive substances.

QF13012 - ECTS

 

The main objectives of this UC is to give to the students the skills to understand the principles of evaluation of biological/pharmacological activities of new or chemically substances and the importance of this area in the process of drug discovery and development.

QF13008 - ECTS

It is intended that students become capable of, for the various types of drugs, interpreting and foreseeing their structure-activity relationships, metabolism, as well as the mechanisms of action at a molecular level.  At the end of the CU, students must have a broad and integrated understanding of the entire chemical and pharmaceutical drugs discovery, planning, and development. The CU also aims to promote and develop critical thinking, teamwork and autonomy. At the end of the CU, students should be able to easily communicate their ideas, collaborate and work in team and to be able to solve problems using the scientific and investigational method.

QF13014 - ECTS

With this CU is intended that the student:

- Acquire knowledge about the strategies and methodologies used in research work in progress by the Professors,

- acquire knowledge about the strategies and methodologies used in pharmaceutical chemistry work in the pharmaceutical industry,

- be able to perform a literature review on topics chosen by students from the various themes presented by the Supervisor team,

- acquire knowledge concerning the "state of the art" of the theme to be developed in the dissertation or the project.

QF13015 - ECTS