Drug Design and Sustainable Synthesis of Drugs

Code:

MI224181

Acronym:

POSFARM

Keywords
Classification	Keyword
OFICIAL	Physical Sciences

Instance: 2023/2024 - 1S

Active?	Yes
Responsible unit:	Organic and Pharmaceutical Chemistry Laboratory
Course/CS Responsible:	MSc in Pharmaceutical Sciences

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MICF	0	MICF - Transition Study Plan 2023/24 - 2024/25 - 2025/26	4	-	3	52	81

Teaching language

Portuguese

Objectives

The general objective of this curricular unit is for the student to get in touch with the various strategies/methodologies for planning and obtaining drugs. Thus, an evolutionary and integrated notion of strategies for the search for new drugs will be presented, namely the classical strategies up to the so-called "rational" planning, which involves computational molecular modeling techniques for a planning based on ligand or on the structure of the biological target using X-ray crystallography studies. It is also intended to give an idea of ​​the methodologies used in the sustainable procurement and manufacture of drugs.
The existence of the course unit of Planning and Sustainable Procurement of Pharmaceuticals is justified by the need to complement the content of the course units of Pharmaceutical Chemistry, generalist by nature, with a set of essential knowledge to accompany the Pharmaceutical Industry in the evolution that has undergone of new drugs.

 

 

Learning outcomes and competences

The student should obtain:

Working method

Presencial

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

It is assumed students have the basic knowledge provided by the subjects: Organic Chemistry I, Organic Chemistry II, Pharmaceutical Chemistry I, Biochemistry, Pharmacology and Instrumental Analysis Methods.

 

 

Program

 

 

 

Introduction and development of the concepts applied to the discovery and design of new drugs:

- Biodiversity as a source of drugs in a sustained manner

- Green Chemistry in the Pharmaceutical Industry

- "Tools" used in the discovery and design of drugs: Computational Chemistry, X-Ray Crystallography ,  Chromatography

- The importance of ADMET studies in drug discovery
- Good pratices of manufacturing
- Intelectual Property and drug development

Practical classes:

- Discussion of the subjects taught in the lectures

- Application of computational chemistry to a practical problems

- The resolution of problems that could be faced in planning and obtaining drugs

- The preparation and presentation by the students of a "problem" on planning a drug

 

 - Visit to a R&D unit

There may be the participation of teachers and / or researchers invited affected to the areas directly related.

 

 

 

 

Mandatory literature

Pinto Madalena M. M. 340; Manual de trabalhos laboratoriais de química orgânica e farmacêutica. ISBN: 978-972-757-750-7

Teaching methods and learning activities

 - Lectures (2 hours / week): MANDATORY PRESENCE presentations on "Power Point"; seeks to provide knowledge in an engaging and deductive manner.The literature sources indicated during class are also considered study material

- Practical classes

- Practical lessons in computational chemistry.

- Computational chemistry exercices indicating what was considered more relevant as learning

- Preparation, monitored by teachers, and presentation by the students of a problem (problem-based learning).

 

keywords

Physical sciences > Chemistry > Organic chemistry
Physical sciences > Chemistry > Computational chemistry
Health sciences > Pharmacological sciences > Pharmacy
Physical sciences > Chemistry > Combinatorial chemistry

Evaluation Type

Distributed evaluation without final exam

Assessment Components

designation	Weight (%)
Prova oral	25,00
Trabalho prático ou de projeto	50,00
Teste	25,00
Total:	100,00

Amount of time allocated to each course unit

designation	Time (hours)
Apresentação/discussão de um trabalho científico	5,00
Elaboração de projeto	50,00
Estudo autónomo	10,00
Frequência das aulas	25,00
Trabalho escrito	10,00
Total:	100,00

Eligibility for exams

 - presence in theoretical classes is mandatory

- Presentation and discussion of a problem/resolution is mandatory.

 

- Students must obtain a minimum score on the "problem-based learning"or final examination more  than 9.5 out of 20.

- If the classification is less than 9.5 students may waive the continuous evaluation and perform final theoretical examination at the time of examination (appeal)

- To obtain approval, students must obtain a final mark of 10 values (sum of all evaluation components).

 

Calculation formula of final grade

- Reports and Presentation and discussion of a "problem-based learning": factor 75%.
Written test of the theoretical course 25%

 

Internship work/project

not applicable

Special assessment (TE, DA, ...)

Students that by law do not need to attend the practical classes, and do not have frequency in these classes must perform a final written exam in date according to the academic calendar
Students with assessments obtained in previous years may give up of the continuous assessment (must contact the Responsible UC) and perform new evaluation; otherwise,  must perform a final written exam in date according to the academic calendar

Classification improvement

Students will have to make a final examination on the theoretical component.