Pharmacology II

Code:

MI074132

Acronym:

FCOL2

Keywords
Classification	Keyword
OFICIAL	Health Sciences

Instance: 2013/2014 - 1S

Active?	Yes
Web Page:	https://moodle.up.pt/course/view.php?id=127
Responsible unit:	Pharmacology Laboratory
Course/CS Responsible:	MSc in Pharmaceutical Sciences

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MICF	204	Official Curriculum	4	-	6,5	65	175,5

Teaching language

Portuguese

Objectives

Study of the mechanisms of action, pharmacokinetic properties and adverse reactions of the most relevant drugs used in the treatment of inflammatory disease and those affecting the cardiovascular, respiratory, endocrine, gastrointestinal and kidney systems.

Learning outcomes and competences

It is intended that the student acquires knowledge enabling him to understand:

a) the mechanism of action of the most important drugs used in the treatment of diseases that affect different organ systems of the body;
b) identify the most common adverse reactions to drugs that in some cases may intrefere with the adesion  to therapy and may require require alteration of the same using other alternative pharmacological approaches;
c) know some of the pharmacokinetic properties of the drugs studied which distinguishes them in terms of duration of action and that may have implications on its route of administration to obtain the desired therapeutic effect.

Working method

Presencial

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

Students should have knowledgements about the function of different organ systems of the human body and their functional relationships.

Program

Imunopharmacology

1 Introduction to imunopharmacology and inflammation
1.1. Signs and characteristics of the inflammatory response
1.2. Mechanisms of host defence: cells and mediators
1.3. Eicosanoides and inflammatory response: role of prostaglandins, tromboxanes, leukotrienes and related compounds
2 Drugs used in inflammation
2.1 Non steroidal anti-inflammatory drugs (NSAIDs)
2.2 Corticosteroids
2.3 Disease-modifying antirheumatic drugs
2.4 Drugs used in gout 

3 Histamine Pharmacology
3.1 Role of histamine in inflammation and allergic reactions
3.2 H1 receptor antagonists
3.3 Histamine and regulation of gastric acid secretion
3.4 Drugs used in peptic ulcer disease
3.4.1 H2 receptor antagonists
3.4.2 Proton pump inhibitors
3.4.3 Antacids
3.4.4 Mucosal protective agents 

4 Drugs used in Asthma and Chronic Pulmonary Obstructive Disorders
4.1 Corticosteroids
4.2 Beta2-Selective adrenoceptor agonists
4.3 Methylxanthines
4.4 Other drugs with prophylactic effect on bronchospasm: leukotriene antagonists, inhibitors of mastocite degranulation, muscarinic antagonists and anti-IgE monoclonal antibodies

Cardiovascular Pharmacology
1. Pharmacology of Cardicac rhythm
1.1. Pathophysiology of Cardiac Electric Disfunction
1.2. Drug classes
1.2.1.General mechanisms of action
1.2.2. Antiarhythmic classes
2. Pharmacology da Cardiac Contractility
2.1. Physiology e Pathophysiology of Contractile dysfunction
2.2. Drug classes
2.2.1. Cardiac glucosides
2.2.2. Beta-adrenergic agents
2.2.3 Phosphodiesterase inhibitors
3. Pharmacology of Volume Regulaion
3.1. Physiology of Volume Regulaion and Pathophysiology of Edema
3.2. Drug classes
3.2.1. Renin-angiotensin system Inhibitors
3.2.2. Diuretics
3.2.3. Other agents
4. Pharmacology of Vascular Tone
4.1. Physiology of the vascular smooth muscle contraction/relaxation
4.2. Drug classes
4.2.1. Nitrates e sodium nitroprusside
4.2.2. Calcium channel blockers
4.2.3.Renin-angiotensin system Inhibitors
4.2.4. Other agents
5. Pharmacology of Hemostase and Thrombose
6. Pharmacology of Lipoprotein and Cholesterol Metabolism
7. Integrative Cardiovascular Pharmacology
7.1. Hypertension
7.2. Congestive Heart Failure
7.3. Isquemic Heart Disease

Endocrine Pharmacology
1. Pharmacology of Thyroid Gland
2. Pharmacology of Reproduction
3. Pharmacology of Endocrine Pancreas

Mandatory literature

Rang H.P., Dale M.M., Ritter J.M., Flower R.J., Henderson G.; Rang and Dale's Pharmacology, 7th Ed. Elsevier , 2012. ISBN: ISBN-13 978-7020-3471-8
Katzung B.G.; Basic and Clinical Pharmacology, 10th Ed. McGrawHill, 2007. ISBN: ISBN-978-007-110441-8
GOODMAN and GILMAN'S; Pharmacological Basis of Therapeutics, 12th Ed., McGraw-Hill, 2013. ISBN: 0071624422

Teaching methods and learning activities

Teaching comprises a theoretical component and experimental one. The theoretical component is of expository nature with the presentation of the most important drugs of each pharmacologic group, guidelines for individual study and resolution of practical cases on the subjects taught.

The experimental component comprises: 1) the completion of a design project for an in vivo essay fot the inestigation of a drug mechanism of action; 2) the execution and interpretation of a number of biological assays were the effects of drugs used in therapy will be tested; 3) the resolution and presentation of a case study on the issues of Integrative Pharmacology covered in theoretical lectures.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

designation	Weight (%)
Exame	75,00
Trabalho laboratorial	25,00
Total:	100,00

Eligibility for exams

- The attendence at theoretical lesson is not compulsory.

- The students must be present in 3/4 of the laboratory classes to obtain frequency and be allowed to perform the final exam.

Calculation formula of final grade

The evaluation will cover all subjects taught in theoretical and practical lessons. Consists of the sum of the component of practical evaluation (5 values) and a final exam (15 values​​) at the end of the semester. For the practical evaluation to be considered, the students must obtain the minimum mark 7,5 values) in the final exam. The final exam will consist of a questionnaire with multiple choice questions.

Special assessment (TE, DA, ...)

Workers students and ERASMUS Students or may waive the laboratory evaluation component.  In this case they will be evaluated only in a final exam that will cover matters of theory and laboratory, including practical cases solved by peers during the semester, and will have a price of 20. ERASMUS Students will have to attend laboratory classes and the workers students and should notify their decision to the responsible of teh discipline, early in the semester.

Classification improvement

According to the evaluation standards of FFUP currently in effect.

The student will have to repeat only the final exam, and the grade obtained will be equal to the sum of the mak obtained in the written examination and of  that obtained in the laboratory component. The final score will be the highest obtained in the tests performed.