Physical-Chemistry

Code:

MI071207

Acronym:

QUIFIS

Keywords
Classification	Keyword
OFICIAL	Physical Sciences

Instance: 2010/2011 - 2S

Active?	Yes
Web Page:	https://sigarra.up.pt/ffup/DISCIPLINAS_GERAL.FORMVIEW?p_ano_lectivo=2009/2010&p_cad_codigo=MI071207&p_periodo=2S
Responsible unit:	Applied Chemistry Laboratory
Course/CS Responsible:	MSc in Pharmaceutical Sciences

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MICF	322	Official Curriculum	1	-	6	65	162

Teaching language

Portuguese

Objectives

The aim of this discipline consists of the study of three large areas of physical-chemistry: thermodynamics, kinetics and binary heterogeneous systems.
This therefore consists of the study of chemical thermodynamics – presentation of thermodynamic concepts, their chemical application and the study of biochemical thermodynamics – their application in the thermodynamic knowledge and interpretation of biological and microbiological phenomena, their application in the areas of life sciences and biotechnology.
In relation to kinetics, this includes not only the study of chemical kinetics and catalysis but also enzymatic kinetics and enzymatic inhibition.
Concerning heterogeneous systems, micelle and liposome systems will be studied, with special emphasis on those applicable as drug delivery systems or for the study of distribution, bioavailability and mechanism of action/interaction with biomembranes of drugs.

Program

Unit 1 - Chemical and Biochemical Thermodynamics
Concepts and thermodynamic definitions
The zero law of thermodynamic
The first law of thermodynamic
Thermochemistry
The second law of thermodynamic
Gibbs function
Free energy and equilibrium
Application of Gibbs function and entropy to biological systems: coupled reactions, phosphate group transfer reactions, and proton transfer reactions.
Biochemical Application of thermodynamics: active and passive transport, sodium-potassium pump, thermodynamics of glucose metabolism.
Unit 2 – Kinetics
Rate of reaction
Rate law
Reaction mechanisms and rate law
Reaction mechanisms based on kinetics and thermodynamics parameters: alkane halogenation and SN1 and SN2 reactions
Chemical Catalysis
Unit 3- Enzyme kinetics and inhibition
Unit 4 – Binary and heterogeneous systems
Introduction to binary phase systems
Phase diagrams
Analytical applications
Introduction to heterogeneous systems
Definition of heterogeneous systems: micelles, vesicles, liposomes, membranes
Importance of studying the interaction of drugs with heterogeneous systems
Heterogeneous systems applied to pharmaceutical technology
Drug delivery using heterogeneous systems
Catalysis using heterogeneous systems
Physico-chemical properties influencing the interaction of drugs with heterogeneous systems
Methodologies for studying the interaction of drugs with heterogeneous systems as biomimetic models of lipidic membranes

Mandatory literature

Chang Raymond; Physical chemistry with applications to biological systems. ISBN: 0-02-321040-0
Atkins Peter; The^elements of physical chemistry. ISBN: 0-19-879290-5
João Sotomayor; Cinética Química, Lidel, 2003. ISBN: 972-757-251-0

Complementary Bibliography

Tinoco Ignacio 070; Physical chemistry: principles and applications in biological sciences. ISBN: 0-13-095943-X
Barrow Gordon M.; Physical chemistry for the life sciences. ISBN: 0-07-003858-9

Teaching methods and learning activities

Theoretical classes: 2 hours / week taught with the help of available audiovisuals.
Practical classes: 1 hour/week. Resolution of application problems.
Laboratory classes: 2 hours / week include experimental work related to the subject-matters taught in the theoretical classes. The tasks are undertaken individually and all experimental observations and further calculus should be kept in a lab notebook.

keywords

Physical sciences > Chemistry > Physical chemistry

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Attendance (estimated)	Participação presencial	70,00
Written test	Exame	2,00		2011-07-16
Laboratorial work	Trabalho laboratorial	2,00		2011-05-30
Lab notebook	Defesa pública de dissertação, de relatório de projeto ou estágio, ou de tese	18,00		2011-05-30
	Total:	-	0,00

Eligibility for exams

The assiduity in the laboratorial classes is compulsory, as established in the Norms of Evaluation of the FFUP.
The presence at the theoretical classes is not mandatory.

Calculation formula of final grade

This is the weighted average of the laboratorial classification (obtained during the semester as the distributed evalution or obtained in the practical test as part of the final exam), that contributes with 20%, and the written or oral exam, that contributes with 80%.

The lab evaluation is quantified (0 to 20) from the students’ performance during the lab classes, from the recording of experimental observations and associated calculus in the lab notebook and also from a written exercise performed during the classes’ period. Students with classification lower than 9.5 will not be approved and should take the practical test at the final exam.
Approval at the laboratory evaluation is a pre-requisite for admission to the written test of the final exam.
The students, who are lawfully allowed to not attend the experimental classes, and hence are not evaluated in a distributed way, will be compulsory expected to perform the practical test and also the oral test in the final exam.

The final exam is composed by three parts:

Practical test – it comprehends all the subjects within the laboratorial component of this discipline. One of the experimental protocols will be performed, accompanied by the respective report. The classification should be given within 0 and 20.
Besides exceptional cases under Law, the practical test will only be available to students that fulfilled the assiduity requirements and had a classification lower than 9.5 in the laboratory evaluation.

Written test – it comprehends all the subjects within the discipline program that were taught. The classification should be given within 0 and 20. Students with classification lower than 8.0 are not approved. Students with classification between 8.0 and 9.5 should take the oral test. . Students with classification higher than 9.5 are excused from the oral test.

Oral test – it comprehends all the subjects within the discipline program that were taught.

Examinations or Special Assignments

The students, who are lawfully allowed to not attend the experimental classes, and hence are not evaluated in a distributed way, will be compulsory expected to perform the practical test and also the oral test in the final exam.

Special assessment (TE, DA, ...)

cf. current FFUP Evaluation Rules

Classification improvement

The students who wish to improve their own classification can make it through the written test of the final examination.

Observations

Students should have knowledge of subject-matters taught in General and Inorganic Chemistry. Students should also have basic knowledge of Biochemistry.