X-chromosome markers in kinship testing: A generalisation of the IBD approach identifying situations where their contribution is crucial

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Nadia Pinto (Autor) Outra; Leonor Gusmao (Autor) Outra; Antonio Amorim (Autor) FCUP

Revista

Título: Forensic Science International: Genetics

Vol. 5

Páginas: 27-32

ISSN: 1872-4973

Editora: Elsevier

Indexação

ISI Web of Knowledge - 54 Citações

Scopus - 65 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

Outras Informações

ID Authenticus: P-002-YKW

DOI: 10.1016/j.fsigen.2010.01.011

Abstract (EN): The standard practice of forensic kinship evaluation uses unlinked autosomal markers. However, X-chromosome markers have recently gained recognition as a powerful tool to complement the information provided by autosomes, particularly in complex cases. In this paper, the X-chromosome mode of transmission is addressed in the theoretical identity-by-descent framework. Formulas for the joint genotypic probabilities considering various pedigrees relating two inbred and/or non-inbred individuals are derived. Finally, the importance of X-chromosome markers is highlighted by the fact that, in addition to complementing the autosomal information, X-chromosome transmission allows differential weighting of certain hypotheses regarding pedigrees belonging to the same autosomal class, i.e., pedigrees that are indistinguishable by the use of unlinked autosomal markers. Illustrative examples of common kinship testing are shown.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6