Anticipation of presbyopia in Portuguese familial amyloidosis ATTR V30M

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

beirao, m (Autor) Outra; matos, e (Autor) Outra; beirao, i (Autor) ICBAS; costa, ppe (Autor) ICBAS; torres, p (Autor) Outra

Revista

Título: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

Vol. 18

Páginas: 92-97

ISSN: 1350-6129

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 5 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-002-N8Z

DOI: 10.3109/13506129.2011.576719

Abstract (EN): The aim of this study was to evaluate if Portuguese patients with familial amyloidosis, liver transplanted and not, have an earlier development of presbyopia compared with a normal population and its relation with the presence or the absence of anterior capsule opacification of the lens. This study was performed to evaluate if Portuguese patients with familial amyloidosis and in a blood donors population (control group). Three hundred and fifty-six subjects, 144 amyloidotic patients and 212 healthy individuals, were evaluated for the need of plus lenses for normal near reading (Jaeger chart 1 at 33 cm). In familial amyloidosis patients, the value of the add-power was related to age, liver transplantation status, and presence of visible anterior capsule opacification of the lens. In both groups, the value of add-power was positively correlated with age (r = 0.91; P < 0.005). Familial amyloidosis patients require more add-power than control individuals of similar age, and need to use reading glasses at earlier ages. The age of onset of presbyopia in familial amyloidosis patients was significantly lower than in control individuals (32 years vs. 42 years). Adjusting for age, no significant difference was observed in add-power values between liver transplanted and not transplanted amyloidotic patients, suggesting that liver transplantation has no influence on presbyopia evolution in these patients. Familial amyloidosis patients had an earlier onset of presbyopia, probably related to amyloid deposition on the anterior capsule of the lens, which is not halted by liver transplantation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6