Anticipation of presbyopia in Portuguese familial amyloidosis ATTR V30M

• Type: Article in International Scientific Journal
• Date: 2011

Authors

beirao, m (Author) Other; matos, e (Author) Other; beirao, i (Author) ICBAS; costa, ppe (Author) ICBAS; torres, p (Author) Other

Journal

Title: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

Vol. 18

Pages: 92-97

ISSN: 1350-6129

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 5 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-002-N8Z

DOI: 10.3109/13506129.2011.576719

Abstract (EN): The aim of this study was to evaluate if Portuguese patients with familial amyloidosis, liver transplanted and not, have an earlier development of presbyopia compared with a normal population and its relation with the presence or the absence of anterior capsule opacification of the lens. This study was performed to evaluate if Portuguese patients with familial amyloidosis and in a blood donors population (control group). Three hundred and fifty-six subjects, 144 amyloidotic patients and 212 healthy individuals, were evaluated for the need of plus lenses for normal near reading (Jaeger chart 1 at 33 cm). In familial amyloidosis patients, the value of the add-power was related to age, liver transplantation status, and presence of visible anterior capsule opacification of the lens. In both groups, the value of add-power was positively correlated with age (r = 0.91; P < 0.005). Familial amyloidosis patients require more add-power than control individuals of similar age, and need to use reading glasses at earlier ages. The age of onset of presbyopia in familial amyloidosis patients was significantly lower than in control individuals (32 years vs. 42 years). Adjusting for age, no significant difference was observed in add-power values between liver transplanted and not transplanted amyloidotic patients, suggesting that liver transplantation has no influence on presbyopia evolution in these patients. Familial amyloidosis patients had an earlier onset of presbyopia, probably related to amyloid deposition on the anterior capsule of the lens, which is not halted by liver transplantation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6