Antioxidant phenolic esters with potential anticancer activity: solution equilibria studied by Raman spectroscopy

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

machado, n. f. l. (Autor) Outra; calheiros, r. (Autor) Outra; gaspar, a. (Autor) Outra; garrido, j. (Autor) Outra; borges, f. (Autor) FCUP; marques, m. p. m. (Autor) Outra

Revista

Título: Journal of Raman Spectroscopy

Vol. 40

Páginas: 80-85

ISSN: 0377-0486

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 20 Citações

Scopus - 21 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências Físicas > Química

Outras Informações

ID Authenticus: P-003-R34

DOI: 10.1002/jrs.2083

Abstract (EN): The solution Raman pattern of a series of structurally related hydroxycinnamic and hydroxybenzoicesters (caffeates and gallates) with potential antioxidant/anticancer activity was studied, for different biologically significant concentrations. The spectra were assigned with the help of theoretical calculations in the light of previously reported experimental data for these compounds in the solid state. Evidence of the formation of dimeric entities in solution, via (C)=O center dot center dot H(O) and/or (C)=O center dot center dot center dot H(C) intermolecular hydrogen bonds, was obtained. The dimer-to-monomer equilibrium, which influences the antioxidant activity of this kind of systems, was monitored through Raman titration experiments. Copyright (c) 2008 John Wiley & Sons, Ltd.

Idioma: Inglês

Tipo (Avaliação Docente): Científica