Antioxidant phenolic esters with potential anticancer activity: solution equilibria studied by Raman spectroscopy

• Type: Article in International Scientific Journal
• Date: 2009

Authors

machado, n. f. l. (Author) Other; calheiros, r. (Author) Other; gaspar, a. (Author) Other; garrido, j. (Author) Other; borges, f. (Author) FCUP; marques, m. p. m. (Author) Other

Journal

Title: Journal of Raman Spectroscopy

Vol. 40

Pages: 80-85

ISSN: 0377-0486

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 21 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Physical sciences > Chemistry

Other information

Authenticus ID: P-003-R34

DOI: 10.1002/jrs.2083

Abstract (EN): The solution Raman pattern of a series of structurally related hydroxycinnamic and hydroxybenzoicesters (caffeates and gallates) with potential antioxidant/anticancer activity was studied, for different biologically significant concentrations. The spectra were assigned with the help of theoretical calculations in the light of previously reported experimental data for these compounds in the solid state. Evidence of the formation of dimeric entities in solution, via (C)=O center dot center dot H(O) and/or (C)=O center dot center dot center dot H(C) intermolecular hydrogen bonds, was obtained. The dimer-to-monomer equilibrium, which influences the antioxidant activity of this kind of systems, was monitored through Raman titration experiments. Copyright (c) 2008 John Wiley & Sons, Ltd.

Language: English

Type (Professor's evaluation): Scientific