Magnetoliposomes Containing Multicore Nanoparticles and a New Antitumor Thienopyridine Compound with Potential Application in Chemo/Thermotherapy

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Lopes, FAC (Autor) Outra; Fernandes, AVF (Autor) Outra; Rodrigues, JM (Autor) Outra; Queiroz, MJRP (Autor) Outra; Almeida, BG (Autor) Outra; Pires, A (Autor) Outra; pereira, a. m. (Autor) FCUP; araujo, j. p. (Autor) FCUP; Castanheira, EMS (Autor) Outra; Rodrigues, ARO (Autor) Outra; Coutinho, PJG (Autor) Outra

Revista

Título: Biomedicines

Vol. 12

Página Final: 1547

Editora: MDPI

Indexação

ISI Web of Knowledge - 10 Citações

Scopus - 11 Citações

Outras Informações

ID Authenticus: P-00W-TSY

DOI: 10.3390/biomedicines10071547

Abstract (EN): Multicore magnetic nanoparticles of manganese ferrite were prepared using carboxymethyl dextran as an agglutinating compound or by an innovative method using melamine as a cross-coupling agent. The nanoparticles prepared using melamine exhibited a flower-shape structure, a saturation magnetization of 6.16 emu/g and good capabilities for magnetic hyperthermia, with a specific absorption rate (SAR) of 0.14 W/g. Magnetoliposome-like structures containing the multicore nanoparticles were prepared, and their bilayer structure was confirmed by FRET (Forster Resonance Energy Transfer) assays. The nanosystems exhibited sizes in the range of 250-400 nm and a low polydispersity index. A new antitumor thienopyridine derivative, 7-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]thieno[3,2-b]pyridine, active against HeLa (cervical carcinoma), MCF-7 (breast adenocarcinoma), NCI-H460 (non-small-cell lung carcinoma) and HepG2 (hepatocellular carcinoma) cell lines, was loaded in these nanocarriers, obtaining a high encapsulation efficiency of 98 +/- 2.6%. The results indicate that the new magnetoliposomes can be suitable for dual cancer therapy (combined magnetic hyperthermia and chemotherapy).

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16