Magnetoliposomes Containing Multicore Nanoparticles and a New Antitumor Thienopyridine Compound with Potential Application in Chemo/Thermotherapy

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Lopes, FAC (Author) Other; Fernandes, AVF (Author) Other; Rodrigues, JM (Author) Other; Queiroz, MJRP (Author) Other; Almeida, BG (Author) Other; Pires, A (Author) Other; pereira, a. m. (Author) FCUP; araujo, j. p. (Author) FCUP; Castanheira, EMS (Author) Other; Rodrigues, ARO (Author) Other; Coutinho, PJG (Author) Other

Journal

Title: Biomedicines

Vol. 12

Final page: 1547

Publisher: MDPI

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00W-TSY

DOI: 10.3390/biomedicines10071547

Abstract (EN): Multicore magnetic nanoparticles of manganese ferrite were prepared using carboxymethyl dextran as an agglutinating compound or by an innovative method using melamine as a cross-coupling agent. The nanoparticles prepared using melamine exhibited a flower-shape structure, a saturation magnetization of 6.16 emu/g and good capabilities for magnetic hyperthermia, with a specific absorption rate (SAR) of 0.14 W/g. Magnetoliposome-like structures containing the multicore nanoparticles were prepared, and their bilayer structure was confirmed by FRET (Forster Resonance Energy Transfer) assays. The nanosystems exhibited sizes in the range of 250-400 nm and a low polydispersity index. A new antitumor thienopyridine derivative, 7-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]thieno[3,2-b]pyridine, active against HeLa (cervical carcinoma), MCF-7 (breast adenocarcinoma), NCI-H460 (non-small-cell lung carcinoma) and HepG2 (hepatocellular carcinoma) cell lines, was loaded in these nanocarriers, obtaining a high encapsulation efficiency of 98 +/- 2.6%. The results indicate that the new magnetoliposomes can be suitable for dual cancer therapy (combined magnetic hyperthermia and chemotherapy).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16