A parallel increase in placental oxidative stress and antioxidant defenses occurs in pre-gestational type 1 but not gestational diabetes

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Araujo, JR (Autor) Outra; ramalho, c (Autor) FMUP; Correia Branco, A (Autor) Outra; Faria, A (Autor) FCUP; Ferraz, T (Autor) Outra; Keating, E (Autor) FMUP; Martel, F (Autor) FMUP

Revista

Título: Placenta

Vol. 34

Páginas: 1095-1098

ISSN: 0143-4004

Editora: Elsevier

Indexação

ISI Web of Knowledge - 15 Citações

ISI Web of Science

Scopus - 17 Citações

Pubmed / Medline

Classificação Científica

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-008-FR9

DOI: 10.1016/j.placenta.2013.09.001

Abstract (EN): We aimed to determine the oxidative stress status in placentas obtained from gestational (GDM) and type 1 (T1D) diabetic pregnancies. Malonaldehyde and protein carbonyls, two biomarkers of oxidative damage, were higher in T1D but not in GDM placentas. Also, higher reduced glutathione and lower oxidized glutathione levels and higher glutathione peroxidase activity were found in T1D but not in GDM placentas. These results suggest that T1D placentas may develop a protective antioxidant mechanism to overcome higher oxidative stress levels.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Notas: <a href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS&DestLinkType=FullRecord&KeyUT=:000326772600020">Indexado na ISI Web of Science</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/24054539">Indexado na Pubmed</a>

Nº de páginas: 4