A parallel increase in placental oxidative stress and antioxidant defenses occurs in pre-gestational type 1 but not gestational diabetes

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Araujo, JR (Author) Other; ramalho, c (Author) FMUP; Correia Branco, A (Author) Other; Faria, A (Author) FCUP; Ferraz, T (Author) Other; Keating, E (Author) FMUP; Martel, F (Author) FMUP

Journal

Title: Placenta

Vol. 34

Pages: 1095-1098

ISSN: 0143-4004

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 15 Citations

ISI Web of Science

Scopus - 17 Citations

Pubmed / Medline

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-008-FR9

DOI: 10.1016/j.placenta.2013.09.001

Abstract (EN): We aimed to determine the oxidative stress status in placentas obtained from gestational (GDM) and type 1 (T1D) diabetic pregnancies. Malonaldehyde and protein carbonyls, two biomarkers of oxidative damage, were higher in T1D but not in GDM placentas. Also, higher reduced glutathione and lower oxidized glutathione levels and higher glutathione peroxidase activity were found in T1D but not in GDM placentas. These results suggest that T1D placentas may develop a protective antioxidant mechanism to overcome higher oxidative stress levels.

Language: English

Type (Professor's evaluation): Scientific

Notes: <a href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS&DestLinkType=FullRecord&KeyUT=:000326772600020">Indexado na ISI Web of Science</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/24054539">Indexado na Pubmed</a>

No. of pages: 4