Association between CYP2E1 polymorphisms and susceptibility to prostate cancer

• Tipo: Artigo em Revista Científica Internacional
• Data: 2003

Autores

Ferreira, PM (Autor) Outra; Rui Medeiros (Autor) Outra; Vasconcelos, A (Autor) Outra; Costa, S (Autor) Outra; Pinto, D (Autor) Outra; Morais, A (Autor) Outra; Oliveira, J (Autor) Outra; Lopes, C (Autor) ICBAS

Revista

Título: European Journal of Cancer Prevention

Vol. 12

Páginas: 205-211

ISSN: 0959-8278

Editora: Wolters Kluwer Health

Indexação

ISI Web of Knowledge - 32 Citações

Scopus - 36 Citações

Outras Informações

ID Authenticus: P-000-GCS

DOI: 10.1097/01.cej.0000073081.42031.54

Abstract (EN): Several genetic alterations have been associated with sporadic prostate cancer (PCa). In this study, the association between Rsal and Dral polymorphisms of CYP2E1 and PCa risk was analysed in a case-control study of 227 individuals using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Regarding Dral polymorphisms, the DD genotype is over-represented in PCa cases when compared with the control group (odds ratio (OR) 2.12; 95% confidence interval (CI) 1.11-4.05; P = 0.022). Regarding the Rsal polymorphism, no significant differences were found. The results of this study indicate that Dral polymorphisms of the CYP2E1 gene may be associated with a twofold increased risk for the development of PCa. (C) 2003 Lippincott Williams Wilkins.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7