Association between CYP2E1 polymorphisms and susceptibility to prostate cancer

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Ferreira, PM (Author) Other; Rui Medeiros (Author) Other; Vasconcelos, A (Author) Other; Costa, S (Author) Other; Pinto, D (Author) Other; Morais, A (Author) Other; Oliveira, J (Author) Other; Lopes, C (Author) ICBAS

Journal

Title: European Journal of Cancer Prevention

Vol. 12

Pages: 205-211

ISSN: 0959-8278

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 32 Citations

Scopus - 36 Citations

Other information

Authenticus ID: P-000-GCS

DOI: 10.1097/01.cej.0000073081.42031.54

Abstract (EN): Several genetic alterations have been associated with sporadic prostate cancer (PCa). In this study, the association between Rsal and Dral polymorphisms of CYP2E1 and PCa risk was analysed in a case-control study of 227 individuals using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Regarding Dral polymorphisms, the DD genotype is over-represented in PCa cases when compared with the control group (odds ratio (OR) 2.12; 95% confidence interval (CI) 1.11-4.05; P = 0.022). Regarding the Rsal polymorphism, no significant differences were found. The results of this study indicate that Dral polymorphisms of the CYP2E1 gene may be associated with a twofold increased risk for the development of PCa. (C) 2003 Lippincott Williams Wilkins.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7