Rodent versions of the Iowa gambling task: opportunities and challenges for the understanding of decision-making

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

de Visser, L (Autor) Outra; Homberg, JR (Autor) Outra; Mitsogiannis, M (Autor) Outra; Zeeb, FD (Autor) Outra; Rivalan, M (Autor) Outra; Fitoussi, A (Autor) Outra; Galhardo, V (Autor) FMUP; van den Bos, R (Autor) Outra; Winstanley, CA (Autor) Outra; Dellu Hagedorn, F (Autor) Outra

Revista

Título: Frontiers in Neuroscience

Vol. 5

ISSN: 1662-4548

Editora: Frontiers Media

Indexação

ISI Web of Knowledge - 114 Citações

Scopus - 86 Citações

Outras Informações

ID Authenticus: P-008-25K

DOI: 10.3389/fnins.2011.00109

Abstract (EN): Impaired decision-making is a core problem in several psychiatric disorders including attention-deficit/hyperactivity disorder, schizophrenia, obsessive compulsive disorder, mania, drug addiction, eating disorders, and substance abuse as well as in chronic pain. To ensure progress in the understanding of the neuropathophysiology of these disorders, animal models with good construct and predictive validity are indispensable. Many human studies aimed at measuring decision-making capacities use the Iowa gambling task (IGT), a task designed to model everyday life choices through a conflict between immediate gratification and long-term outcomes. Recently, new rodent models based on the same principle have been developed to investigate the neurobiological mechanisms underlying IGT-like decision-making on behavioral, neural, and pharmacological levels. The comparative strengths, as well as the similarities and differences between these paradigms are discussed. The contribution of these models to elucidate the neurobehavioral factors that lead to poor decision-making and to the development of better treatments for psychiatric illness is considered, along with important future directions and potential limitations.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 21