Detection of additional structural variation at the FES/FPS system and population data from S. Tome e Principe and North Portugal

• Tipo: Artigo em Revista Científica Internacional
• Data: 1999

Autores

Pereira, L (Autor) Outra; Gusmao, L (Autor) Outra; Prata, MJ (Autor) FCUP; Mota, P (Autor) Outra; Trovoada, MJ (Autor) Outra; Amorim, A (Autor) FCUP

Revista

Título: International Journal of Legal Medicine

Vol. 112

Páginas: 204-206

ISSN: 0937-9827

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 4 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

Outras Informações

ID Authenticus: P-001-4QB

DOI: 10.1007/s004140050235

Abstract (EN): Comparative analysis of heteroduplex patterns on the STR FES/FPS sq stem led to the detection of a new non-consensus allele 10 in the African population of Sao Tome e Principe. Automated sequencing confirmed a T-->C substitution at position 177 (1(st)T of the 6(th) repeat) which was exclusively found in haplotypic combination with base A in the previously described polymorphic position 34, The new substitution was not detected in a sample from North Portugal. Sequence analysis revealed a triplet of inverted bases, from positions 101 to 103. relative to the sequence described in the GeneBank (Accession No. X06292), This work confirms the capacity of heteroduplex analysis in the detection of DNA structural microvariation and emphasises the complementary utility of manual system analysis and semi-automated techniques for a full characterisation of the genetic variability of STRs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3