Voltammetric oxidation of drugs of abuse - II. Codeine and metabolites

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Garrido, Jorge M P J (Autor) Outra; Delerue-Matos, C. M Delerue (Autor) Outra; Borges, Fernanda Fernanda M (Autor) FFUP; Macedo, Tice Reis A (Autor) Outra; Oliveira-Brett, A. M. (Autor) Outra

Revista

Título: Electroanalysis

Vol. 16

Páginas: 1427-1433

ISSN: 1040-0397

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 38 Citações

Scopus - 40 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências Físicas > Química

Outras Informações

ID Authenticus: P-000-8NR

DOI: 10.1002/elan.200302967

Abstract (EN): The oxidation of codeine on glassy carbon electrodes has been studied in detail using differential pulse voltammetry. The results obtained using a glassy carbon electrode clearly show a much more complex oxidation mechanism than that previously reported when platinum and gold electrodes were used. To clarify the codeine oxidative profile, several metabolites and analogues of this alkaloid, codeine N-oxide, norcodeme, dihydrocodeine, acetylcodeine and 6-chlorodesoxycodeine, were synthesized and studied. It was deduced that the anodic waves observed in codeine oxidation are related to the presence of methoxy, hydroxy and tertiary amine groups. Due to the similarity of potentials at which these oxidative processes take place, at some pHs an overlap of peaks occurs and only one anodic wave is observed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica