Cardiovascular (reverse) remodelling induced by pregnancy: looking at the right side of the heart

• Tipo: Resumo de Comunicação em Conferência Internacional
• Data: 2024

Autores

Ferreira, AF (Autor) Outra; Araujo, J (Autor) Outra; Azevedo, MJ (Autor) Outra; Saraiva, FA (Autor) Outra; Diaz, SO (Autor) Outra; Sousa, C (Autor) FMUP; Machado, AP (Autor) Outra; Benedita Sampaio-Maia (Autor) FMDUP; Ramalho, C (Autor) Outra; Leite Moreira, A (Autor) Outra; Barros, AS (Autor) FMUP; Santos, M (Autor) Outra; Falcao Pires, (Autor) Outra

Ata de Conferência Internacional

Título: EUROPEAN HEART JOURNAL

European-Society-Of-Cardiology Congress (Esc)

London (ENGLAND), Aug 30 - 02 Sep

Indexação

ISI Web of Knowledge - 0 Citações

Outras Informações

ID Authenticus: P-017-FJK

DOI: 10.1093/eurheartj/ehae666.3230

Abstract (EN): <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Introduction</jats:title> <jats:p>Many studies have focused on pregnancy-induced left ventricular remodelling, overlooking the changes in right cardiac chambers.</jats:p> </jats:sec> <jats:sec> <jats:title>Purpose</jats:title> <jats:p>To characterize the right cardiovascular (CV) remodelling and reverse remodelling (RR) induced by pregnancy and postpartum, respectively, and the impact of CV risk (CVR) factors on these processes.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>This prospective cohort was recruited at two tertiary centers from 2019 to 2022, including 51 healthy and 79 obese and/or hypertensive and/or with gestational diabetes and/or smoking habits pregnant women (cardiovascular risk [CVR] group). Women were evaluated by transthoracic echocardiography at the 1st trimester (1T) and 3rd trimester (3T) of pregnancy, as well as one-month (PP1), six-months (PP2), and one-year postpartum (PP3). Generalized linear mixed-effects models were used for the analysis of right CV remodelling and RR and to evaluate the impact of CVR factors on these processes.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>This study included 130 pregnant women, 60.8% primiparous, with a median age of 33 years. Despite all echocardiographic results being within the normality range, we describe the progression of right heart adaptations throughout pregnancy and postpartum (Table 1), namely: 1) Similar enlargement of the right atrium (RA) and right ventricle (RV) dimensions throughout pregnancy, recovering at PP2 except for RA in the CVR group; 2) Preserved RV systolic function throughout pregnancy in both groups, while the postpartum hemodynamic normalization triggers a reduction of (TAPSE) and tricuspid S' wave velocity; 3) Reduced RA strain in both groups during pregnancy, more evident in CVR group, which had a slower postpartum recovery; 4) Preserved RV global longitudinal strain (GLS) throughout follow-up time, being significantly reduced in 3T of CVR group and recovering at PP2; 5) Reduction of tricuspid E/A ratio from 1T to 3T in both groups with an early recovery at PP1, being these values significantly higher in the healthy group, and 6) Steady pulmonary artery systolic pressure (PASP) values throughout follow-up time, showing consistently higher values in the CVR group.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>This study describes the subclinical right cardiac functional and structural changes within the physiological range, which recover 6 months after delivery. CVR factors impact the magnitude of the subclinical RV diastolic function changes, PASP and myocardial deformation (strain) without any impact on classic RV systolic function.</jats:p> </jats:sec>

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 1