Could the PI3K canonical pathway be a common link between chronic inflammatory conditions and oral carcinogenesis?

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2016

Autores

Sonis, ST (Autor) Outra; Mendes, RA (Autor) Outra

Revista

Título: Journal of Oral Pathology & Medicine

Vol. 45

Páginas: 469-474

ISSN: 0904-2512

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 14 Citações

Outras Informações

ID Authenticus: P-00T-FFE

DOI: 10.1111/jop.12436

Abstract (EN): The association between chronic inflammatory disorders and oral carcinogenesis has been both a source of interest and contention. Based upon its central importance in oral carcinogenesis, the finding that the PI3k/Akt/mTOR pathway is activated in oral lichen planus, chronic graftversus-host disease, and chronic oral candidiasis suggests that it may provide a link between benign and malignant oral conditions. Here, we discuss a possible mechanistic rationale that addresses the activation of this important signaling pathway and its downstream events, while correlating it with the carcinogenic potential of chronic oral disorders.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6