Plasmonic/magnetic liposomes based on nanoparticles with multicore-shell architecture for chemo/thermotherapy

• Tipo: Artigo em Livro de Atas de Conferência Internacional
• Data: 2022

Autores

Rodrigues, ARO (Autor) Outra; Santos, LCA (Autor) Outra; Macedo, DO (Autor) Outra; Rio, ISR (Autor) Outra; Pires, A (Autor) Outra; pereira, a. m. (Autor) FCUP; araujo, j. p. (Autor) FCUP; Castanheira, EMS (Autor) Outra; Coutinho, PJG (Autor) Outra

Ata de Conferência Internacional

Título: Journal of Physics: Conference Series

5th International Conference on Applications of Optics and Photonics, AOP 2022

17 July 2022 through 22 July 2022

Indexação

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-00X-Q7Q

DOI: 10.1088/1742-6596/2407/1/012051

Abstract (EN): Multifunctional nanosystems are capable to carry one or more therapeutic agents (thermal and/or targeting agents and chemotherapeutic drugs), offering the capability to concurrently perform different treatment modalities using a single nanosystem. Cluster nanostructures, consisting of densely packed aggregates of magnetic nanoparticles, have shown enhanced heating capabilities. Their combination with plasmonic nanoparticles enable synergistic behavior between dual hyperthermia (magneto-photothermia), allowing overheating cancer cells while increasing drug toxicity. In this work, multicore magnetic nanoparticles (NPs) of MnFe2O4 were prepared using oxamide and melamine as clustering agents. The multicore NPs prepared with oxamide were covered with a gold shell, resulting in multicore magnetic/plasmonic NPs with an increased SAR of 173.80 W/g, under NIR light. Liposomes based on these magnetic/plasmonic NPs were prepared and the model drug curcumin was loaded in these nanocarriers with a high encapsulation efficiency. The fusion between the curcumin-loaded magnetic/plasmonic liposomes and models of cell membranes (labelled with Nile Red) was confirmed by FRET, pointing the magneto/plasmonic liposomes as promising for dual cancer therapy (combined hyperthermia and chemotherapy). © Published under licence by IOP Publishing Ltd.

Idioma: Inglês

Tipo (Avaliação Docente): Científica