The PORtromb Project: prothrombin G20210A mutation and venous thromboembolism in young people

• Tipo: Artigo em Revista Científica Internacional
• Data: 2002

Autores

Mansilha A. (Autor) FMUP; araujo, f (Autor) Outra; Sampaio, S (Autor) Outra; Ribeiro, LMC (Autor) Outra; Braga, A (Autor) Outra

Revista

Título: Cardiovascular surgery

Vol. 10

Páginas: 45-48

ISSN: 0967-2109

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 7 Citações

Outras Informações

ID Authenticus: P-000-QCG

DOI: 10.1016/s0967-2109(00)00150-2

Abstract (EN): Recently a new identified genetic variant in the 3'-untranslated region of the prothrombin gene (G20210A allele) associated with increased plasma prothrombin levels has been linked to an increased risk of venous thromboembolism (VTE). To determine the importance of this G20210A allele as a causative risk factor for WE in the general population, we analysed the data of an epidemiologic investigation on thrombophilia in young people, the Oporto Thrombophilia Study (PORtromb). Forty cases (mean,age: 27 yr old) with a first episode of WE under 40 yr old, and 100 healthy subjects, were evaluated. Heterozygosity for the G20210A allele was present in 12.5% of WE cases and in 5% of controls, indicating a possible marginal increase of WE risk in carriers of the allele (odds ratio: 2.71: 95% CI 0.74-9.95).

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4