Carboxyxanthones: Bioactive Agents and Molecular Scaffold for Synthesis of Analogues and Derivatives

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2019

Autores

Ribeiro, J (Autor) Outra; Veloso, C (Autor) Outra; Carla Fernandes (Autor) FFUP; M E Tiritan (Autor) FFUP; Pinto, MMM (Autor) Outra

Revista

Título: Molecules

Vol. 24

Página Final: 180

ISSN: 1420-3049

Editora: MDPI

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 19 Citações

Outras Informações

ID Authenticus: P-00Q-394

DOI: 10.3390/molecules24010180

Abstract (EN): Xanthones represent a structurally diverse group of compounds with a broad range of biological and pharmacological activities, depending on the nature and position of various substituents in the dibenzo--pyrone scaffold. Among the large number of natural and synthetic xanthone derivatives, carboxyxanthones are very interesting bioactive compounds as well as important chemical substrates for molecular modifications to obtain new derivatives. A remarkable example is 5,6-dimethylxanthone-4-acetic acid (DMXAA), a simple carboxyxanthone derivative, originally developed as an anti-tumor agent and the first of its class to enter phase III clinical trials. From DMXAA new bioactive analogues and derivatives were also described. In this review, a literature survey covering the report on carboxyxanthone derivatives is presented, emphasizing their biological activities as well as their application as suitable building blocks to obtain new bioactive derivatives. The data assembled in this review intends to highlight the therapeutic potential of carboxyxanthone derivatives and guide the design for new bioactive xanthone derivatives.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 33