Setting definitions of childhood asthma in epidemiologic studies

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Silva, D (Autor) Outra; Severo, M (Autor) Outra; Paciência, I (Autor) Outra; Rufo, J (Autor) Outra; Martins, C (Autor) Outra; Moreira, Pedro (Autor) FCNAUP; Padrão, Patrícia (Autor) FCNAUP; Delgado, L (Autor) Outra; Moreira, André (Autor) FMUP

Revista

Título: Pediatric Allergy and Immunology

ISSN: 0905-6157

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 18 Citações

Scopus - 18 Citações

Classificação Científica

CORDIS: Ciências da Saúde

FOS: Ciências médicas e da saúde

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-00Q-Z1W

DOI: 10.1111/pai.13111

Abstract (EN): Background: The definitions of childhood asthma differ among epidemiological studies. We aimed to compare the diagnostic accuracy and agreement of previous asthma definitions and to evaluate questionnaire-driven asthma definition patterns. Methods: Data on 808 participants aged 7-12 years from 20 schools were analyzed. Asthma definitions based on symptoms assessed by questionnaire, parent-reported medical asthma diagnosis, current use of asthma medication, airway reversibility after bronchodilatation, and increased (¿35 ppb) levels of exhaled nitric oxide (eNO) were compared with a gold standard (medical diagnosis of asthma with asthma symptoms in the past 12 months and/or airway reversibility). Concordance was assessed by Cohen's kappa. Data-driven analysis was applied to the questionnaire, and six scores were determined ¿asthma,¿ ¿rhinitis,¿ ¿cough,¿ ¿non-specific respiratory symptoms,¿ ¿treated asthma,¿ and ¿uncontrolled asthma.¿ Tree decisions were built using these scores. Results: Definitions of asthma based on respiratory symptoms, airway reversibility, and parent-reported medical diagnosis had a low sensitivity but high specificity. Agreement between reported and objective measures was poor. Parent-reported medical asthma diagnosis, but not reversibility or eNO, was able to predict questionnaire-driven symptom patterns. Decision trees indicated that those with recent non-specific respiratory symptoms had a higher probability of positive bronchodilation. Conclusion: A standardized operational definition of asthma should include a composite score based on reported asthma medical diagnosis, symptoms, and lung function. © 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Idioma: Inglês

Tipo (Avaliação Docente): Científica