General Toxicology

Code:

B381

Acronym:

B381

Keywords
Classification	Keyword
OFICIAL	Biology

Instance: 2014/2015 - 1S

Active?	Yes
Responsible unit:	Department of Biology
Course/CS Responsible:	Bachelor in Biology

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
L:AST	2	Plano de Estudos a partir de 2008	3	-	5	42	135
L:B	123	Plano de estudos a partir de 2008	3	-	5	42	135
L:F	0	Plano de estudos a partir de 2008	3	-	5	42	135
L:G	3	P.E - estudantes com 1ª matricula anterior a 09/10	3	-	5	42	135
		P.E - estudantes com 1ª matricula em 09/10	3	-	5	42	135
L:M	0	Plano de estudos a partir de 2009	3	-	5	42	135
L:Q	18	Plano de estudos Oficial	3	-	5	42	135

Teaching language

Portuguese

Objectives

General Toxicology aims to provide basic knowledge in this area- The main contaminants will be analised form a toxicological point of view. National and international examples in the area of Toxicology will be provided to the students.   Theoretical concenpts related to the intoxication porcessw will be explained, the systemic toxicology, the methodologies for the plannification oif toxicity asays and the analiysis of results.

Learning outcomes and competences

By the end of this course students should be able to use the concepts learned in real situations of environmental pollution or in the evaluation of the toxicology and ecotoxicology of chemical substances. 

Working method

Presencial

Program

Lectures:  Module 1- Principles of Toxicology; dimnamics and persistence of toxicants in organisms; distribution of toxicants in organisms; bioaccumulation, bioconcentration and bioamplification of toxicants.  Depuration, excretion and biotransformation of toxicants. Dinamics of intoxication.

 Module 2 - Toxicity and relashionship dose(concentration)/responses. Biological variability, intra and inter specific. Selection of assay species. Dose/response curves and most common toxicity measures: DL50, CL50, CE50 and others. Plannification of toxicity assays. Factors that affect toxicity. Applications of Toxicology: Forensic, clinical, ocupational and environmental toxicology

Module 3 –Systemic Toxicology: responses of the immunological syste; liver, kidney, respiratory and nervous systems; skin and reproductory system. Case study: endocrine disruptors.

Module 4 –Terrestrial Ecotoxicology: test organisms, exposure routes, soil tests.  Risk evaluation: predictive and retrospective. Integration of toxicity data to determine risk levels.

 

Mandatory literature

W. Carmichael; The Water Environment: Algal Toxins and Health

Teaching methods and learning activities

Theoretical lectures with audiovisual support (powerpoint) and the slides will be made available to students via SIGARRA.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

designation	Weight (%)
Prova oral	15,00
Teste	70,00
Trabalho escrito	15,00
Total:	100,00

Amount of time allocated to each course unit

designation	Time (hours)
Elaboração de relatório/dissertação/tese	0,00
Total:	0,00

Eligibility for exams

Students should have at least 30% in each of the tests, presentations, report and final exam. The lack of report and oral presentation implies failure. Students should attend the minimum amount of pratical sessions according with geleral rules of FCUP

Calculation formula of final grade

Option 1-  Test 1 - 7 points; Test 2 - 7points; Presentation- 3 Points; Individual report- 3 points; TOTAL - 20 Points

Opção 2 - Final exam- 14 Points; Presentation- 3 points Individual report- 3 points; TOTAL - 20 Points.

The evaluation of the theorerical part is done by two tests or final exam.  If the student is not approved in the test can only have is final examination on the 2nd exam.

Observations

BIBLIOGRAFIA Abel, P.D., 1998. Water Pollution Biology. Taylor & Francis, London. 286 pp Bartell, S.M., Gardner R.H., & O’Neill, R.V., 1992. Ecological Risk Estimation. Lewis Publishers, Chelsea, USA: 252 pp Calow, P., 1993. Handbook of Ecotoxicology. Vol. I. Blackwell Scientific Publications. Oxford. 478 pp Casarett and Doull's, 1991. Toxicology. The Basic Science of Poisons. Amdur, M., Doull, J., Klaassen, C. (eds.). Pergamon Press. NY: 1033 pp Graney, R.L., Kennedy, J.H., & J.H. Rodger, J.R., 1994. Aquatic Mesocosm Studies in Ecological Risk Assessment. Lewis Publishers, U.S.ª: 723 pp Huggett, R.J., Kimerle, R.ª, Mehrle, Jr., P.M., & Bergman, H.L., 1992. Biomarkers. Biochemical, Physiological and Histological Markers of Antropogenic Stress. Lewis Publihsers,. Chelsea, USA: 347 pp Manahan, S.E., 1992. Toxicological Chemistry. 2nd Ed. Lewis Publishers, Michigan, 449 pp Manahan, S.E., 1994. Environmental Chemistry. 6th Edition. Lewis Publishers, Michigan, 811 pp Moriarty, F., 1990. Ecotoxicology. 2nd Ed. Academic Press. London, 289 pp Persoone, G., Jaspers, E. & Claus, C., 1984a. Ecotoxicology testing for the marine environment. Vol. I State University of Ghent & Institute of Marine Scientific Research Bredene, Belgium, 771 pp Persoone, G., Jaspers, E. & Claus, C., 1984a. Ecotoxicology testing for the marine environment. Vol. II State University of Ghent & Institute of Marine Scientific Research Bredene, Belgium, 588 pp Rand, G.M., 1995. Fundamentals of Aquatic Toxicology. Taylor & Francis, London: 216 pp Shaw I.C., & Chadwick, J., 1998. Principles of Environemtal Toxicology. Taylor & Francis, London, 216 pp Truhaut, R., 1977. Ecotoxicology: objectives, principles and perspectives. Ecotoxicoluy and Environmental Safety, 2:418-424 Walker, C.H., Hopkin, S.P., Sibly, R.M., & Peakall, D.B., 1997. Principles of Ecotoxicology. Taylor & Francis, London: 321 pp WHO. 1984. Aquatic (marine and freshwater) biotoxins. International Programme on Chemical Safety. World Health Organization, Geneva. Environmental Health Criteria 37:95 pp