Going "Green" in the Prevention and Management of Atherothrombotic Diseases: The Role of Dietary Polyphenols

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Reis, A (Author) Other; Rocha, S (Author) Other; Victor de Freitas (Author) FCUP

Journal

Title: Journal of Clinical Medicine

Vol. 120

Final page: 1490

ISSN: 2077-0383

Publisher: MDPI

Indexing

ISI Web of Knowledge - 9 Citations

Other information

Authenticus ID: P-00T-W6Q

DOI: 10.3390/jcm10071490

Abstract (EN): During the 20th century processed and ready-to-eat foods became routinely consumed resulting in a sharp rise of fat, salt, and sugar intake in people's diets. Currently, the global incidence of obesity, raised blood lipids, hypertension, and diabetes in an increasingly aged population contributes to the rise of atherothrombotic events and cardiovascular diseases (CVD) mortality. Drug-based therapies are valuable strategies to tackle and help manage the socio-economic impact of atherothrombotic disorders though not without adverse side effects. The inclusion of fresh fruits and vegetables rich in flavonoids to human diets, as recommended by WHO offers a valuable nutritional strategy, alternative to drug-based therapies, to be explored in the prevention and management of atherothrombotic diseases at early stages. Though polyphenols are mostly associated to color and taste in foods, food flavonoids are emerging as modulators of cholesterol biosynthesis, appetite and food intake, blood pressure, platelet function, clot formation, and anti-inflammatory signaling, supporting the health-promoting effects of polyphenol-rich diets in mitigating the impact of risk factors in atherothrombotic disorders and CVD events. Here we overview the current knowledge on the effect of polyphenols particularly of flavonoid intake on the atherothrombotic risk factors and discuss the caveats and challenges involved with current experimental cell-based designs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 23