Systems Biology and Bioprocesses

Code:

BIOL4057

Acronym:

BIOL4057

Level:

400

Keywords
Classification	Keyword
OFICIAL	Biology

Instance: 2019/2020 - 2S

Active?	Yes
Responsible unit:	Department of Biology
Course/CS Responsible:	Master in Applications in Biotechnology and Synthetic Biology

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
M:ABBS	19	The study plan from 2019/20	1	-	6	42	162

Teaching language

Portuguese

Objectives

It is intended with this course to address basic concepts of systems biology and bioprocesses by framing them in different case studies. The acquired competences will be fundamental for the insertion in different areas of labor market like the Food Industry, Pharmaceutical, Cosmetic (or others) and in laboratories of research and development or other industrial environments.

Learning outcomes and competences

The syllabus contents are in coherence with the learning objectives insofar as the knowledge of the different topics studied, will allow a better integration of the student in an industrial environment.

Theoretical-practical case studies involving different aspects of Systems Biology and Bioprocesses were selected.

Working method

Presencial

Program

Chapter 1 - Basic Concepts of Reaction Kinetics in Bioprocesses.

- Mathematical descriptions of biological kinetics; Reactive-kinetics in biological contexts; Rational Reactions and Heat

Chapter 2 - Mass balances

- Foundations for the calculation of mass balances; Open Systems vs Closed Systems; Status and non-stationary state

Chapter 3 - Energy balances

-Calculation of enthalpies; Cases of study in reactional systems

Chapter 4 - Biological Systems: Case Studies

-Generalities and general concepts; Single and multiphase systems; Types of reactors in an industrial environment

Chapter 5 - Systems Biology: State Space Models

-Models of biological systems, simple examples. The Hill equation;Linear state space models; nner stability and BIBO stability; Controllability, state space feedback, pole placement, stabilization; state feedback control and state estimation.

Chapter 6 - Systems Biology: Compartment Models

-Definition; state space models; Analysis of the evolution of the total mass of the system and mass control algorithms; Analysis of the evolution of the total mass of the system and mass control algorithms.

Mandatory literature

Nelson Lima, Manuela Mota;; Biotecnologia- Fundamentos e Aplicações, 2003. ISBN: ISBN 972-757-197-2
Pauline Doran; Bioprocess Engineering Principles. ISBN: 978-0-12-220851-5
João Miranda Lemos; Controlo no Espaço de Estados, 2019. ISBN: 9789898481702
Chi-Tsong Chen; Linear system theory and design. ISBN: 0-19-511777-8

Teaching methods and learning activities

The theoretical-practical classes are divided into classes with data-show projections of PowerPoint slides that are previously made available to students and in research classes and case study presentations.

Students should present a final research paper on a previously selected topic in the field of Biology Systems and Bioprocesses.

 

Frequency acquisition

Class attendance, according to the FCUP regulations.

 

Evaluation method

40% research work evaluation + 60% final written exam.

Final grade of the written exam must be higher than 8 out of 20.

Software

MATLAB

Evaluation Type

Distributed evaluation with final exam

Assessment Components

designation	Weight (%)
Exame	60,00
Trabalho prático ou de projeto	40,00
Total:	100,00

Amount of time allocated to each course unit

designation	Time (hours)
Elaboração de projeto	60,00
Estudo autónomo	80,00
Frequência das aulas	22,00
Total:	162,00

Eligibility for exams

Frequency acquisition

Class attendance, according to the FCUP regulations.

Calculation formula of final grade

Evaluation method

40% research work evaluation + 60% final written exam.

Final grade of the written exam must be higher than 8 out of 20.