Biochemistry II

Code:

CN21001

Acronym:

BIOQII

Keywords
Classification	Keyword
OFICIAL	Physical Sciences
OFICIAL	Health Sciences

Instance: 2012/2013 - 1S

Active?	Yes
Web Page:	http://bioquimica.med.up.pt/ensino/index.html
Course/CS Responsible:	Nutrition Sciences

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
CNUP	83	Plano oficial	2	-	5	49	135

Teaching language

Portuguese

Objectives

This course follows a sequence of disciplines that, as a whole, aim to be coherent.
Thus, based on knowledge and training in terms of biochemical thinking acquired in the previous units of Organic Chemistry and Biochemistry I, the intention is to start learning the most important chapters of human metabolism, for the integrated understanding of health status and some diseases, selected by criteria of prevalence and / or exemplary teaching.
It is not intended that students learn to describe by heart the metabolic pathways, but learn to know how to read them as you read a map, seeing as the intermediate metabolites are related to each other, where are the key regulatory points and how the different pathways integrate, where are active enzymes affected by known diseases, or enzymes that are drugs or poisons targets, and also to understand how changes in one system can lead to changes in other systems.
The knowledge that allow us to understand why one diet is better than another, what are the nutritional needs of people in the various stages of development, several instances of health or disease, and also the basis on which to interpret and evaluate data that they acquire about the risks and health benefits of certain dietary changes are mostly in biochemistry.
It is understandable, that contents in this unit are essential knowledge for someone wishing to have a successful and autonomous future with a degree in Nutrition and Food Sciences.

Program

Overall introduction to the Course. Digestion and absorption of carbohydrates.
Study of carbohydrate metabolism and its regulation, namely: glycolysis, piruvate oxidation, pentose-phosphate pathway, NADPH consumption, glycogenesis, glycogenolysis, glyconeogenesis and metabolism of galactose, fructose and glucoronate . Study of the pathways that are common in the oxidation of all nutrients (Krebs cycle and oxidative phosphorylation) and its relationship with the formation and hydrolysis of ATP. General overview of carbohydrate metabolism.
Structure and function of lipids. Digestion and absorption of lipids. Study of lipidic metabolism and their regulation. Namely: synthesis and oxidation of fatty acids, metabolism of ketone bodies, synthesis of phospholipids and glycolipids, structure and metabolism of plasma lipoproteins, metabolism of triacylglycerols, metabolism of cholesterol and bile acids. Radicals and oxidative stress defense mechanisms, anti-oxidants. Integration of carbohydrate and lipidic metabolism.

Teaching methods and learning activities

Weekly, 2 lectures of 1 hour each and a small group class (AG) of 1h30 in a total of 49 hours per student.

Evaluation Type

Evaluation with final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Attendance (estimated)	Participação presencial	45,50
	Total:	-	0,00

Eligibility for exams

Assessment will be made through a written exam (E), with a series of multiple-choice questions (group I), and 2 groups of questions, group II with 6 proposals (the student chooses to answer only four question) and group III with 3 proposals (the student chooses to answer only one question). The result obtained in the exam (E) will be adjusted according to the mark obtained in the continuous evaluation obtained in the small group classes (AG).

Observations

Baynes JW, Dominiczak MH.: Medical Biochemistry. 3rd. Ed. Elsevier Mosby. New York. 2009.
Berg J.M., Tymoczko J.L. and Stryer L.: Biochemistry. 6th. Ed. International Edition. W.H. Freeman and Company. New York. 2006.
Brody T.: Nutritional Biochemistry. 2nd. Ed. Academic Press. San Diego. 1999.
Murray R.K., Granner D.K., Mayes P.A. and Rodwell V.W.: Harper's Illustrated Biochemistry. 28th. Ed.. McGraw-Hill Medical. London. 2009.
Nelson D.L., Cox M.M.: Lehningher Principles of Biochemistry (4th Ed.). W.H. Freeman and Company, New York. 2005.
Stipanuk M.H.: Biochemical, Physiological, Molecular Aspects of Human Nutrition. 2nd. Ed. Saunders Elsevier. St. Louis. 2006.