Solubility Enhancement of Hydrophobic Compounds in Aqueous Solutions Using Biobased Solvents as Hydrotropes

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Silva, SS (Autor) Outra; Abranches, DO (Autor) Outra; Pinto, AS (Autor) Outra; Soares, BP (Autor) Outra; Passos, H (Autor) FEUP; Ferreira, AM (Autor) Outra; Coutinho, JAP (Autor) Outra

Revista

Título: Industrial & Engineering Chemistry Research

Vol. 62

ISSN: 0888-5885

Editora: American Chemical Society

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Y-TRK

DOI: 10.1021/acs.iecr.3c01469

Abstract (EN): Improving the aqueous solubility of poorly soluble hydrophobiccompounds is a topic of great interest to the pharmaceutical, chemical,and food industries. The poor solubility of these compounds in waterposes a challenge in developing sustainable processes for their extraction,separation, and formulation. Therefore, in this study, the use ashydrotropes of biobased solvents such as & gamma;-valerolactone (GVL),Cyrene, ethyl lactate, and alkanediols (1,2-propanediol, 1,5-pentanediol,and 1,6-hexanediol) to improve the solubility of two model compounds(syringic acid and ferulic acid) in water is investigated. The effectsof the concentration and structure of biobased solvents on the solubilityof phenolic compounds in aqueous solutions at (303.2 & PLUSMN; 0.5) Kwere studied. The results showed that the aqueous solubility of thephenolic compounds studied typically increased with the log (K (OW)) of the hydrotrope (1,2-propanediol <Cyrene < 1,5-pentanediol < GVL < ethyl lactate < 1,6-hexanediol)and the hydrophobicity of the solute; the hydrotropic dissolutionof phenolic compounds is shown to depend on both the hydrotrope andthe solute. This study shows that some biobased solvents, especiallyGVL, are excellent hydrotropes. Their renewable nature, low price,and low toxicity make these results particularly relevant to the fieldof extraction and separation of bioactive compounds.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8