Water-Soluble Saccharina latissima Polysaccharides and Relation of Their Structural Characteristics with In Vitro Immunostimulatory and Hypocholesterolemic Activities

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Moreira, ASP (Autor) Outra; Gaspar, D (Autor) Outra; Ferreira, SS (Autor) Outra; Alexandra Correia (Autor) ICBAS; Manuel Vilanova (Autor) ICBAS; Perrineau, MM (Autor) Outra; Kerrison, PD (Autor) Outra; Gachon, CMM (Autor) Outra; Domingues, MR (Autor) Outra; Coimbra, MA (Autor) Outra; Coreta-Gomes, FM (Autor) Outra; Nunes, C (Autor) Outra

Revista

Título: Marine Drugs

Vol. 21

Página Final: 183

ISSN: 1660-3397

Editora: MDPI

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 3 Citações

Outras Informações

ID Authenticus: P-00Y-74X

DOI: 10.3390/md21030183

Abstract (EN): Brown macroalgae are an important source of polysaccharides, mainly fucose-containing sulphated polysaccharides (FCSPs), associated with several biological activities. However, the structural diversity and structure-function relationships for their bioactivities are still undisclosed. Thus, the aim of this work was to characterize the chemical structure of water-soluble Saccharina latissima polysaccharides and evaluate their immunostimulatory and hypocholesterolemic activities, helping to pinpoint a structure-activity relationship. Alginate, laminarans (F1, neutral glucose-rich polysaccharides), and two fractions (F2 and F3) of FCSPs (negatively charged) were studied. Whereas F2 is rich in uronic acids (45 mol%) and fucose (29 mol%), F3 is rich in fucose (59 mol%) and galactose (21 mol%). These two fractions of FCSPs showed immunostimulatory activity on B lymphocytes, which could be associated with the presence of sulphate groups. Only F2 exhibited a significant effect in reductions in in vitro cholesterol's bioaccessibility attributed to the sequestration of bile salts. Therefore, S. latissima FCSPs were shown to have potential as immunostimulatory and hypocholesterolemic functional ingredients, where their content in uronic acids and sulphation seem to be relevant for the bioactive and healthy properties.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15