SEPARATION OF ENANTIOMERS OF 1A,2,7,7A-TETRAHYDRO-3-METHOXYNAPHTHA-(2,3B)-OXIRANE BY LIQUID-CHROMATOGRAPHY - LABORATORY-SCALE ELUTION CHROMATOGRAPHY AND MODELING OF SIMULATED MOVING-BED

• Tipo: Artigo em Revista Científica Internacional
• Data: 1995

Autores

Alírio Rodrigues (Autor) FEUP; LU, ZP (Autor) Outra; José Miguel Loureiro (Autor) FEUP; PAIS, LS (Autor) Outra

Revista

Título: Journal of Chromatography A

Vol. 702 Nº 1

Páginas: 223-231

ISSN: 0021-9673

Editora: Elsevier

Indexação

ISI Web of Knowledge - 25 Citações

Scopus - 27 Citações

Outras Informações

ID Authenticus: P-001-GWA

DOI: 10.1016/0021-9673(94)01037-f

Abstract (EN): The separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane (Sandoz epoxide) on cellulose triacetate HPLC columns was investigated on the laboratory scale. The performance of the columns was calculated by HEFT measurements and the slopes of the adsorption equilibrium isotherms and effective diffusivities were calculated from elution chromatographic experiments. Multi-component adsorption equilibrium isotherms were calculated from single isotherms by using the ideal adsorbed solution (IAS) model. Simulation of continuous chromatographic separation of the racemic mixture of Sandoz epoxide in a simulated moving bed was carried out and the effect of mass transfer coefficient on process performance was analysed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9