Lisinopril and diltiazem reduce left ventricular mass without changing blood pressure in normotensive subjects with exaggerated blood pressure response to exercise

• Tipo: Artigo em Revista Científica Internacional
• Data: 1996

Autores

Polonia, J (Autor) FMUP; Martins, L (Autor) Outra; Macedo, F (Autor) FMUP; Faria, DB (Autor) Outra; Simoes, L (Autor) Outra; Brandao, F (Autor) Outra; Gomes, MC (Autor) Outra

Revista

Título: Revista Portuguesa de Cardiologia

Vol. 15 Nº 6

Páginas: 185-193+179

ISSN: 0870-2551

Editora: Sociedade Portuguesa De Cardiologia

Indexação

ISI Web of Knowledge

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-007-6YD

Abstract (EN): Objective: To determine whether high left ventricular mass may be reduced by antihypertensive drugs in normotensives with exaggerated blood pressure response to exercise as it occurs in hypertensive patients. Design and methods: Randomized, single blind, controlled parallel study evaluating the influence of placebo, lisinopril 20 mg/day, diltiazem 180 mg/d for 5-6 months on left ventricular mass (LVM), evaluated by echo and on 'casual' and 24-h ambulatory blood pressure (24-h BP) in normotensive subjects with exaggerated blood pressure response to exercise (Group I) and in weight - and age - matched mild-moderated hypertensive patients (Group II), all with high left ventricular mass. Patients: Placebo, lisinopril and diltiazem, were administered for 5-6 months in respectively 8+9+9 subjects of Group I and 8+9+10 patients of Group II. Results: Placebo did not change either LVM index or 24-h BP values in Group I and Group II. Diltiazem and lisinopril reduced LVM index in both Groups I and II but 24-h BP values were only reduced in Group II. Lisinopril appeared to be more potent than diltiazem on LVM regression. Slopes of LVM index regression were not different between Groups I and II for each drug. Drug-induced changes of LVM index did not correlate with blood pressure changes. Conclusions: Drug-induced regression of LVM may be achieved in man (Group I) without any reduction of blood pressure. This may be explained by interference with growth-promoting systems other than with cardiac unloading. Also, the similar pattern of LVM regression that was observed in both Groups I and II suggests that similar underlying mechanisms may be involved in the LVH regression in these two populations.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9