Nano- and Microdelivery Systems for Marine Bioactive Lipids

• Type: Another Publication in an International Scientific Journal
• Date: 2014

Authors

David M Pereira (Author) FFUP; Patricia Valentao (Author) FFUP; Paula B Andrade (Author) FFUP

Journal

Title: Marine Drugs

Vol. 12

Pages: 6014-6027

ISSN: 1660-3397

Publisher: MDPI

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 9 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-00A-2DR

DOI: 10.3390/md12126014

Abstract (EN): There is an increasing body of evidence of the positive impact of several marine lipids on human health. These compounds, which include omega-3 polyunsaturated fatty acids, have been shown to improve blood lipid profiles and exert anti-inflammatory and cardioprotective effects. The high instability of these compounds to oxidative deterioration and their hydrophobicity have a drastic impact in their pharmacokinetics. Thus, the bioavailability of these compounds may be affected, resulting in their inability to reach the target sites at effective concentrations. In this regard, micro/nanoparticles can offer a wide range of solutions that can prevent the degradation of targeted molecules, increase their absorption, uptake and bioavailability. In this work we will present the options currently available concerning micro- and nanodelivery systems for marine lipids; with emphasis on micro/nanoparticles; such as micro/nanocapsules and emulsions. A wide range of bottom-up approaches using casein, chitosan, cyclodextrins, among others; will be discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14