Pericardial NT-Pro-BNP and GDF-15 as Biomarkers of Atrial Fibrillation and Atrial Matrix Remodeling in Aortic Stenosis

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Fragao Marques, M (Author) FMUP; Barroso, I (Author) Other; Farinha, R (Author) Other; miranda, im (Author) FMUP; Martins, D (Author) Other; Mancio, J (Author) FMUP; Rocha Neves, J (Author) FMUP; guimaraes, jt (Author) Other; Leite-Moreira AF (Author) FMUP; Falcao Pires, I (Author) FMUP

Journal

Title: Diagnostics

Vol. 117

Final page: 1422

Publisher: MDPI

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00V-CDC

DOI: 10.3390/diagnostics11081422

Abstract (EN): Aims: This study aimed to evaluate the association of GDF-15 and NT-pro-BNP in two different biological matrices with AF in severe aortic stenosis patients undergoing aortic valve replacement surgery (AVR), its association with atrial matrix remodeling, as well as with 30-day postoperative outcomes. Main Methods: One hundred and twenty-six patients between 2009 and 2019 with severe aortic stenosis undergoing AVR surgery in a tertiary hospital were assessed. Key Findings: pericardial fluid GDF-15 and pericardial fluid and serum NT-pro-BNP were increased in AF patients with aortic stenosis. COL1A1 and COL3A1 gene expression increased when pericardial fluid NT-pro-BNP values were higher. TIMP4 was positively correlated with pericardial fluid GDF-15. Significance: GDF-15 and NT-pro-BNP in the pericardial fluid are biomarkers of atrial fibrillation in aortic stenosis and correlate with atrial matrix remodeling. AKI is predicted by both serum and pericardial fluid GDF-15.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16