Pericardial NT-Pro-BNP and GDF-15 as Biomarkers of Atrial Fibrillation and Atrial Matrix Remodeling in Aortic Stenosis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Fragao Marques, M (Autor) FMUP; Barroso, I (Autor) Outra; Farinha, R (Autor) Outra; miranda, im (Autor) FMUP; Martins, D (Autor) Outra; Mancio, J (Autor) FMUP; Rocha Neves, J (Autor) FMUP; guimaraes, jt (Autor) Outra; Leite-Moreira AF (Autor) FMUP; Falcao Pires, I (Autor) FMUP

Revista

Título: Diagnostics

Vol. 117

Página Final: 1422

Editora: MDPI

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 11 Citações

Outras Informações

ID Authenticus: P-00V-CDC

DOI: 10.3390/diagnostics11081422

Abstract (EN): Aims: This study aimed to evaluate the association of GDF-15 and NT-pro-BNP in two different biological matrices with AF in severe aortic stenosis patients undergoing aortic valve replacement surgery (AVR), its association with atrial matrix remodeling, as well as with 30-day postoperative outcomes. Main Methods: One hundred and twenty-six patients between 2009 and 2019 with severe aortic stenosis undergoing AVR surgery in a tertiary hospital were assessed. Key Findings: pericardial fluid GDF-15 and pericardial fluid and serum NT-pro-BNP were increased in AF patients with aortic stenosis. COL1A1 and COL3A1 gene expression increased when pericardial fluid NT-pro-BNP values were higher. TIMP4 was positively correlated with pericardial fluid GDF-15. Significance: GDF-15 and NT-pro-BNP in the pericardial fluid are biomarkers of atrial fibrillation in aortic stenosis and correlate with atrial matrix remodeling. AKI is predicted by both serum and pericardial fluid GDF-15.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16