Biological Chemistry II

Code:

MIM126

Acronym:

QB2

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2015/2016 - 2S

Active?	Yes
Responsible unit:	Chemistry
Course/CS Responsible:	Integrated Masters Degree in Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIM	244	Plan 2015 to 2017	1	-	6	72	162

Teaching language

Portuguese

Objectives

1. To rationalize living systems in terms of basic Chemistry principles. To present Biological Chemistry as a mere subset of Chemistry.

2. To correlate knowledge from Organic and Inorganic Chemistry with Biological Chemistry.

3. To aquire specific knowledge about biological molecules and and cellular chemistry organization.

Learning outcomes and competences

1. Knowledge of the biologically important carbon compounds reactions and their mechanisms. Basic organic chemistry problem solving.

2. Structural knowledge of the most important types of biological molecules.

3. Understanding of the importance of molecular recognition, intermolecular interaction and the hydrophobic effect in biological chemistry.

4. Ability to explain the function and action mechanism of biological compounds based on its molecular structure and reactivity, namely enzymes' catalysis, kinetics and regulation.

5. Understanding of the main metabolism global organization, namely the integration of anabolism and catabolism made by NAD (and FAD) and ATP (and other NTPs).

Working method

Presencial

Program

Theoretical

1. Nucleophilic substitution and elimination reactions. SN1 and SN2 reactions. Reactive Intermediates in Organic Chehemistry: free radicals, carbocations, carbanions. Electrophiles and Nucleophiles. Homolysis and heterolysis of covalent bonds. SN1 and SN2 reactions. E1 and E2 reactions.

2. Benzenoid aromatic compounds. Polycyclic Aromatic Hydrocarbons and heterocyclic aromatic compounds.

3. Alcohols and phenols: Physical and chemical properties of alcohols and phenols.

4. Aldehydes and ketones. The carbobyl group. Nucleophilic addition and condensation.

5. Carbohydrates-monosacharides. Glycosidic linkage. Oligosacharides and polysacharides.

6. Carboxylic acids and derivatives - Acidity. Nucleophilic substitution.

7. Lipids - The hydrophobic effect. Fatty acids, acylglycerides, phosphoglycerides and sphingolipids. Terpenoids, steroids and icosanoids.

8. Amines - Basicity. Characteristic reactions. Alkaloids and biogenic amines.

9. Proteins - Aminoacids. Peptidic bond. Structure and conformation. Biological functions.

10. Nucleic acids - Nucleotides. DNA and RNA.

11. Basic aspects of primary metabolism organization and energetics.

12. Enzymes - Molecular rcognition. Mechanisms, kinetics and regulation of enzymatic catalysis. Coenzymes and cofactors.

Laboratorial

1. Functional groups identification

2. Polarimetry of carbohidrate solutions

3. Identification of carbohydrates

4. Spectrophotometric measure of human serum total colesterol

5. Denaturation and spectrophotometry of DNA

6. Invertase kinetics

Mandatory literature

José Augusto Pereira; Apontamentos de Química Biológica, 2008
K. Peter, C, Vollhardt, Neil E. Schore; Organic Chemistry Structure and Function, W. H. Freeman and Company, New York, 2003. ISBN: 4th Edition
T. W. Graham Solomons; Organic Chemistry, John Wiley & Sons, Inc, 1998. ISBN: 4th Edition

Teaching methods and learning activities

Theoretical classes, using Powerpoint presentations. Theoretical-practical classes of problem solving and matters related with laboratorial works. Laboratorial classes where the students work in groups of up to 3, following a written protocol.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	100,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Frequência das aulas	189,00
Trabalho laboratorial	96,00
Total:	285,00

Calculation formula of final grade

Abbreviations: 

Final mark (C), available options:

Option 1: Exame divided in assessments A3 and A4. C = ( A3 + A4 ) / 2. Both A3 and A4 include a non-exclusive theoretical-practical part worth 2/20 points. A minimum mark of 9.5/20 in C AND a minimum of 7.0/20 in A3 are the two necessary conditions to obtain approval. The students that do not achieve at least 7,0/20 points in A3 have to use Option 2.

Option 2: Exam E2. C = E2. The exam E2 has three parts: part P1, corresponding to A3 and quoted to 9/20 points, part P2, corresponding to A4 and quoted to 9/20 points, and part TP, theoretical-practical and quoted to 2/20 points. To obtain approval P1+ P2 + TP has to be greater or equal to 9.5 points AND part P1 has to be greater equal to 3.5/20 points.