Role of Ion Channel Remodeling in Endothelial Dysfunction Induced by Pulmonary Arterial Hypertension

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Santos-Gomes, J (Autor) Outra; Le Ribeuz, H (Autor) Outra; Brás-Silva C (Autor) FMUP; Antigny, F (Autor) Outra; Adão, R (Autor) FMUP

Revista

Título: Biomolecules

Vol. 109

Página Final: 484

ISSN: 2218-273X

Editora: MDPI

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 3 Citações

Outras Informações

ID Authenticus: P-00W-AJZ

DOI: 10.3390/biom12040484

Abstract (EN): <jats:p>Endothelial dysfunction is a key player in advancing vascular pathology in pulmonary arterial hypertension (PAH), a disease essentially characterized by intense remodeling of the pulmonary vasculature, vasoconstriction, endothelial dysfunction, inflammation, oxidative stress, and thrombosis in situ. These vascular features culminate in an increase in pulmonary vascular resistance, subsequent right heart failure, and premature death. Over the past years, there has been a great development in our understanding of pulmonary endothelial biology related to the genetic and molecular mechanisms that modulate the endothelial response to direct or indirect injury and how their dysregulation can promote PAH pathogenesis. Ion channels are key regulators of vasoconstriction and proliferative/apoptotic phenotypes; however, they are poorly studied at the endothelial level. The current review will describe and categorize different expression, functions, regulation, and remodeling of endothelial ion channels (K+, Ca2+, Na+, and Cl¿ channels) in PAH. We will focus on the potential pathogenic role of ion channel deregulation in the onset and progression of endothelial dysfunction during the development of PAH and its potential therapeutic role.</jats:p>

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 30