Separation of chiral mixtures in real SMB units: The FlexSMB-LSRE®

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Pedro Sá Gomes (Author) FEUP; Miriam Zabkova (Author) Other; Michal Zabka (Author) FEUP; Mirjana Minceva (Author) Other; Alírio E. Rodrigues (Author) FEUP

Journal

Title: AICHE Journal

Pages: 125-142

ISSN: 0001-1541

Publisher: Wiley-Blackwell

Indexing

ISI Web of Science

Scopus

INSPEC

COMPENDEX

Scientific classification

FOS: Engineering and technology > Chemical engineering

CORDIS: Technological sciences > Engineering > Chemical engineering

Other information

DOI: 10.1002/aic.11962

Abstract (EN): In this work, a procedure for the separation of a racemic mixture of guaifenesin onto a chiral stationary phase (Chiralpak AD), by means of Simulated Moving Bed (SMB) technology, is presented in four major steps: (1) search for the suitable stationary and mobile phases; (2) determination of sorption parameters and validation by frontal analysis; (3) modeling and design of the SMB unit; and (4) operation and demonstration. A major emphasis is given to the common deviations that real SMB units present when compared with the theoretical apparatus (due to tubing and equipment dead volumes, switching time asymmetries and delays, pumps flow rates variations). These deviations are analyzed before and after the design and construction of the FlexSMB-LSRE® unit, a new flexible unit, hereby presented. A detailed model that takes into account tubing and equipment dead volumes, as well as switching time asymmetries and delay, was used to study and compare different dead volumes design and compensating strategies. It is shown that all these approaches can be converged into a switching time compensating strategy. This approach served to predict the experimental operating conditions and run a classical SMB experiment, which afterwards was compared with the simulated profiles obtained for the FlexSMB-LSRE® unit. The result of the separation was guaifenesin enantiomers with purities above 98% and a productivity value of 23 genantiomer/(dm3 CSP day).

Language: English

Type (Professor's evaluation): Scientific