Thermodynamic and kinetic study of adsorption of R, S-α –Tetralol enantiomers on the chiral adsorbent CHIRALPAK AD

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Michal Zabka (Author) FEUP; Alírio Rodrigues (Author) FEUP

Journal

Title: Separation Science and Technology

Vol. 42 No. 4

Pages: 739-768

ISSN: 0149-6395

Publisher: Taylor & Francis

Indexing

ISI Proceedings

Scientific classification

CORDIS: Technological sciences > Engineering > Chemical engineering

Other information

Resumo (PT): SIMULATED MOVING-BED; LIQUID-CHROMATOGRAPHY; STATIONARY PHASES; PROTEIN SEPARATION; MASS-TRANSFER; DIFFUSION; TEMPERATURE; ADDITIVES; MIXTURES; DESIGN

Abstract (EN): Experimental results for the separation of S,R-alpha-Tetralol enantiomers obtained on preparative columns packed with particle size 20 mu m of chiral adsorbent CHIRALPAK AD are presented. The total porosity was measured by using the non-retained compound 1,3,5-Tri-tert-butylbenzene and was 0.61. The permeability of the bed packed with CHIRALPAK AD was calculated as 4.4 x 10(-13) m(2). The efficiency of columns was characterized by the height equivalent to a theoretical plate (HETP) and a linear dependency has been found over tested flow rates. The HETP of S-alpha-Tetralol and R-alpha-Tetralol calculated at the flow rate 5.0 cm(3)/min were 320 mu m and 340 mu m, respectively. Thermodynamic adsorption parameters enthalpy, Delta H and entropy, Delta S, have been calculated from van't Hoff plot. Equilibrium and kinetics of adsorption of single enantiomers and racemic mixture of alpha-Tetralol on CHIRALPAK AD were evaluated as well. The parameters for multicomponent isotherm linear-Langmuir model are presented. The breakthrough curves of alpha-Tetralol enantiomers are simulated with a mathematical model that accounts for axial dispersion and linear driving force for the intraparticle mass transfer.

Language: Portuguese

Type (Professor's evaluation): Scientific