Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Gomes, A (Autor) Outra; Ferraz, R (Autor) Outra; Ficker, L (Autor) Outra; Collins, MS (Autor) Outra; Prudencio, C (Autor) Outra; Cushion, MT (Autor) Outra; Catia Teixeira (Autor) FCUP; Paula Gomes (Autor) FCUP

Revista

Título: Antimicrobial Agents and Chemotherapy

Vol. 62

ISSN: 0066-4804

Editora: American Society for Microbiology

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 5 Citações

Outras Informações

ID Authenticus: P-00P-T02

DOI: 10.1128/aac.00983-18

Abstract (EN): The impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both in vitro and in vivo, we now report the potent action of these compounds on Pneumocystis carinii in vitro. Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8