Structure-activity relationship studies for multitarget antithrombotic drugs

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2016

Autores

Neves, AR (Autor) Outra; Marta Correia da Silva (Autor) FFUP; Emilia Sousa (Autor) FFUP; Pinto, M (Autor) Outra

Revista

Título: Future Medicinal Chemistry

Vol. 8

Páginas: 2305-2355

ISSN: 1756-8919

Editora: Future Medicine Ltd.

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 7 Citações

Outras Informações

ID Authenticus: P-00M-A4G

DOI: 10.4155/fmc-2015-0020

Abstract (EN): Thrombosis is a complex process involving multiple pathways. Currently, therapy relies on the combination of two or more antithrombotic drugs, showing that inhibiting more than one target provides benefits in the prevention and treatment of thrombosis. This review focuses on structure-activity relationship studies of molecules possessing multiple actions against thrombosis, namely, dual inhibitors of coagulation, dual inhibitors of coagulation and platelet aggregation, and also dual inhibitors of platelet aggregation. EP217609 has just entered clinical trials, which raise the expectations on the multitarget strategy to prevent or treat thrombosis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 51