Unravelling exemestane: From biology to clinical prospects

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2016

Autores

Sobral, AF (Autor) Outra; Amaral, C (Autor) Outra; Georgina Correia da Silva (Autor) FFUP; Teixeira, NA (Autor) FFUP

Revista

Título: Journal of Steroid Biochemistry and Molecular Biology

Vol. 163

Páginas: 1-11

ISSN: 0960-0760

Editora: Elsevier

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 19 Citações

Outras Informações

ID Authenticus: P-00M-3A7

DOI: 10.1016/j.jsbmb.2016.03.019

Abstract (EN): Aromatase inhibitors (AIs) are anti-tumor agents used in clinic to treat hormone-dependent breast cancer. AIs block estrogens biosynthesis by inhibiting the enzyme aromatase, preventing tumor progression. Exemestane, a third-generation steroidal AI, belongs to this class of drugs and is currently used in clinic to treat postmenopausal women, due to its high efficacy and good tolerability. Here, its pharmacological and biological aspects as well as its clinical applications and comparison to other endocrine therapeutic agents, are reviewed. It is also focused the benefits and risks of exemestane, drawbacks to be overcome and aspects to be explored.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11