Synthesis of Xanthones and Benzophenones as Inhibitors of Tumor Cell Growth

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Elisangela Costa (Author) Other; Emilia Sousa (Author) FFUP; Nair Nazareth (Author) Other; Maria S J Nascimento (Author) FFUP; Madalena M M Pinto (Author) FFUP

Journal

Title: Letters in Drug Design and Discovery

Vol. 7

Pages: 487-493

ISSN: 1570-1808

Publisher: Bentham Science

Indexing

ISI Proceedings

ISI Web of Knowledge - 18 Citations

Scopus - 19 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-003-4GC

DOI: 10.2174/157018010791526250

Abstract (EN): The synthesis of two new sulfated xanthones and two O-substituted benzophenones was carried out to evaluate for their inhibitory effect on growth of human tumor cell lines. The sulfation of 3,6-(2) and 3,4-dihydroxyxanthone (3) was accomplished using sulfur trioxide-pyridine to give, respectively, xanthone-3,6-O, O-bis(sulfate) (4) and xanthone-3,4-O,O-bis(sulfate) (5). Treatment of 2,2',4,4'-tetrahydroxybenzophenone (6) with acetic acid and prenyl bromide furnished 2,2', 4,4'- tetraacetoxybenzophenone (7) and (5-hydroxy-2,2-dimethylchroman-6-yl)(2'-hydroxy-4'-(tert-pentyloxy) phenyl) methanone (8), respectively. Compounds 2-8 were tested for their effect on the in vitro growth of four representative human tumor cell lines: MCF-7 ER(+) (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), SF-268 (glioma), and A375-C5 (melanoma). Compounds 2 and 7-8 showed an inhibitory activity in the mu M range.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7