Square-Wave Adsorptive-Stripping Voltammetric Detection in the Quality Control of Fluoxetine

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Henri P. A. Nouws (Author) Other; Cristina Delerue-Matos (Author) Other; Aquiles A. Barros (Author) Other; Jose´ A. Rodrigues (Author) Other; Alice Santos-Silva (Author) FFUP; Fernanda Borges (Author) FFUP

Journal

Title: Analytical Letters

Vol. 40 No. 6

Pages: 1131-1146

ISSN: 0003-2719

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 26 Citations

Scopus - 26 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-004-CEJ

Resumo (PT): Electroanalytical methods based on square-wave adsorptive-stripping voltammetry (SWAdSV) and flow-injection analysis with square-wave adsorptive-stripping voltammetric detection (FIA-SWAdSV) were developed for the determination of fluoxetine (FXT). The methods were based on the reduction of FXT at a mercury drop electrode at21.2 V versus Ag/AgCl, in a phosphate buffer of pH 12.0, and on the possibility of accumulating the compound at the electrode surface. The SWAdSV method was successfully applied in the quantification of FXT in pharmaceutical products, human serum samples, and in drug dissolution studies. Because the presence of dissolved oxygen did not interfere significantly with the analysis, it was possible to quantify FXT in several pharmaceutical products using FIA-SWAdSV. This method enables analysis of up to 120 samples per hour at reduced costs. <br> <br> Keywords: Fluoxetine, square-wave adsorptive-stripping voltammetry, flow-injection analysis, electrochemical detection, drug dissolution <br> <a target="_blank" href="http://web.ebscohost.com/ehost/detail?vid=2&hid=21&sid=426227c7-8356-41ec-81a2-3a627602420b%40sessionmgr8&bdata=JnNpdGU9ZWhvc3QtbGl2ZSZzY29wZT1zaXRl#db=a2h&AN=25099851#db=a2h&AN=25099851"> Texto integral </a> <br> <br>

Abstract (EN): Electroanalytical methods based on square-wave adsorptive-stripping voltammetry (SWAdSV) and flow-injection analysis with square-wave adsorptive-stripping voltammetric detection (FIA-SWAdSV) were developed for the determination of fluoxetine (FXT). The methods were based on the reduction of FXT at a mercury drop electrode at21.2 V versus Ag/AgCl, in a phosphate buffer of pH 12.0, and on the possibility of accumulating the compound at the electrode surface. The SWAdSV method was successfully applied in the quantification of FXT in pharmaceutical products, human serum samples, and in drug dissolution studies. Because the presence of dissolved oxygen did not interfere significantly with the analysis, it was possible to quantify FXT in several pharmaceutical products using FIA-SWAdSV. This method enables analysis of up to 120 samples per hour at reduced costs. <br> <br> Keywords: Fluoxetine, square-wave adsorptive-stripping voltammetry, flow-injection analysis, electrochemical detection, drug dissolution <br> <a target="_blank" href="http://web.ebscohost.com/ehost/detail?vid=2&hid=21&sid=426227c7-8356-41ec-81a2-3a627602420b%40sessionmgr8&bdata=JnNpdGU9ZWhvc3QtbGl2ZSZzY29wZT1zaXRl#db=a2h&AN=25099851#db=a2h&AN=25099851"> Full text</a> <br> <br>

Language: Portuguese

Type (Professor's evaluation): Scientific