Dynamics of Lateral Habenula-Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions

• Type: Another Publication in an International Scientific Journal
• Date: 2023-10-27

Authors

Ana Pereira (Author) FMUP; Mobina Alemi (Author) FMUP; Mariana Cerqueira-Nunes (Author) FMUP; Clara Monteiro (Author) FMUP; Vasco Galhardo (Author) FMUP; Helder Cardoso-Cruz (Author) FMUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: NEUROLOGY INTERNATIONAL

Vol. 15 No. 4

Pages: 1303-1319

ISSN: 2035-8377

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Scientific classification

CORDIS: Health sciences > Neuroscience

FOS: Medical and Health sciences ; Medical and Health sciences > Basic medicine

Associated Projects

2022.05193.PTDC - Circuitos dopaminérgicos de codificação de hábitos e dependência em modelos animais de dor crónica

MEMORYSTIM - Modulação optogenética da sinalização GABAérgica e dopaminérgica do córtex préfrontal para a reversão de défices cognitivos relacionados com dor crónica

POCI-01-0145-FEDER-028498 - Codificação de sinais de recompensa em populações neuronais do circuito dopaminérgico: estudo optogenético dos correlatos neuronais de decisão e expectativa

Other information

Authenticus ID: P-00Z-QZJ

DOI: 10.3390/neurolint15040082

Abstract (EN): Chronic pain is a health problem that affects the ability to work and perform other activities, and it generally worsens over time. Understanding the complex pain interaction with brain circuits could help predict which patients are at risk of developing central dysfunctions. Increasing evidence from preclinical and clinical studies suggests that aberrant activity of the lateral habenula (LHb) is associated with depressive symptoms characterized by excessive negative focus, leading to high-level cognitive dysfunctions. The primary output region of the LHb is the ventral tegmental area (VTA), through a bidirectional connection. Recently, there has been growing interest in the complex interactions between the LHb and VTA, particularly regarding their crucial roles in behavior regulation and their potential involvement in the pathological impact of chronic pain on cognitive functions. In this review, we briefly discuss the structural and functional roles of the LHb-VTA microcircuit and their impact on cognition and mood disorders in order to support future studies addressing brain plasticity during chronic pain conditions.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17