The role of Cox-2 expression in the prognosis of dogs with malignant mammary tumours

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Queiroga, FL (Author) Other; Pires, I (Author) Other; Lobo, L (Author) Other; Lopes, C (Author) ICBAS

Journal

Title: Research in Veterinary Science

Vol. 88

Pages: 441-445

ISSN: 0034-5288

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 32 Citations

Scopus - 40 Citations

Other information

Authenticus ID: P-003-6JA

DOI: 10.1016/j.rvsc.2009.10.009

Abstract (EN): s lmmunohistochemical detection of Cyclooxygenase (Cox)-1 and -2 enzymes in canine mammary tumours (CMT) has recently been described. However, the prognostic value of their expression needs to be established. The aim of this study was to investigate Cox (-1 and -2) prognostic value in malignant CMT by evaluating its correlation with clinicopathological parameters (tumour size, histological type, necrosis, lymph node metastasis) and with Disease Free Survival (DES) and Overall Survival (OS). Twenty seven female dogs with malignant tumours were included. Cox-2 expression was associated with lymph node metastasis at surgery time, development of distant metastasis during follow-up (p = 0.038), DFS (p = 0.03) and OS (p = 0.04). Multivariate survival analysis showed that Cox-2 did not retain its significance as an independent prognostic factor. For Cox-1 expression, no statistically significant association was observed. Present study suggests the usefulness of testing Cox-2 specific inhibitors as part of an adjuvant therapy in female dogs with malignant mammary neoplasias.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5