Multi-Matrix Approach for the Analysis of Bicalutamide Residues in Oncology Centers by HPLC-FLD

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Portilha Cunha, MF (Author) Other; Gouveia, TIA (Author) FEUP; Garcia Costa, AL (Author) Other; Arminda Alves (Author) FEUP; Mónica Santos (Author) FEUP

Journal

Title: Molecules

Vol. 26 No. 17

Final page: 5561

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-00V-DZ6

DOI: 10.3390/molecules26185561

Abstract (EN): Cytostatics are toxic pharmaceuticals, whose presence in surfaces puts healthcare workers at risk. These drugs might also end up in hospital effluents (HWW), potentially damaging aquatic ecosystems. Bicalutamide is a cytostatic extensively consumed worldwide, but few analytical methods exist for its quantification and most of them require advanced techniques, such as liquid chromatography mass spectrometry (LC-MS), which are very complex and expensive for large monitoring studies. Therefore, a simple but reliable multi-matrix high performance liquid chromatographic method, with fluorescence detection, was developed and validated to rapidly screen abnormal concentrations of bicalutamide in HWW and relevant contamination levels of bicalutamide in indoor surfaces (>100 pg/cm(2)), prior to confirmation by LC-MS. The method presents good linearity and relatively low method detection limits (HWW: 0.14 ng/mL; surfaces: 0.28 pg/cm(2)). Global uncertainty was below 20% for concentrations higher than 25 ng/mL (HWW) and 50 pg/cm(2) (surfaces); global uncertainty was little affected by the matrix. Therefore, a multi-matrix assessment could be achieved with this method, thus contributing to a holistic quantification of bicalutamide along the cytostatic circuit. Bicalutamide was not detected in any of the grab samples from a Portuguese hospital, but an enlarged sampling is required to conclude about its occurrence and exposure risks.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13