Use of an ether-derived 3-hydroxy-4-pyridinone chelator as a new chromogenic reagent in the development of a microfluidic paper-based analytical device for Fe(III) determination in natural waters

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Moniz, T (Author) Other; Bassett, CR (Author) Other; Almeida, MIGS (Author) Other; Kolev, SD (Author) Other; Maria Rangel (Author) ICBAS; Mesquita, RBR (Author) Other

Journal

Title: Talanta

Vol. 214

ISSN: 0039-9140

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00R-TPE

DOI: 10.1016/j.talanta.2020.120887

Abstract (EN): This article reports on the development and validation of a disposable microfluidic paper-based analytical device (mu PAD) for on-hand, in-situ, and cheap Fe(III) determination in natural waters complying with World Health Organization guidelines. The developed mu PAD used 3-hydroxy-4-pyridinone (3,4-HPO) as a colour reagent due to its considerably lower toxicity than traditionally used iron analytical reagents. It was selected among a group of hydrophilic 3,4-HPO chelators containing ether-derived chains in their structure which were prepared using green methods. The relatively high water solubility of these chelators improved the detection limit and applicability as mu PAD reagents. Under optimal conditions, the mu PAD is characterised by a quantification range between 0.25 and 2.0 mg/L, a detection limit of 55 mu g/L and 15 min of analysis time. The signal stability extends up to 4 h and the device is stable for at least one month. The reagent consumption is below 0.2 mg per analysis and the mu PAD method was validated by analysis certified reference materials and by comparison with atomic absorption results (RD < 10%). The newly developed mu PAD was successfully applied to the determination of iron in river, well and tap waters with no need of any prior sample pre-treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7